Pelvic lipomatosis with cystitis glandularis managed with cyclooxygenase-2 inhibitor: A case report |
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Authors: | Li-Cai Mo Song-Zhe Piao Hai-Hong Zheng Tao Hong Qin Feng Mang Ke |
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Affiliation: | Li-Cai Mo, Song-Zhe Piao, Tao Hong, Qin Feng, Mang Ke, Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated with Wenzhou Medical University, Taizhou 317000, Zhejiang Province, ChinaHai-Hong Zheng, Department of Pathology, Taizhou Hospital of Zhejiang Province Affiliated with Wenzhou Medical University, Taizhou 317000, Zhejiang Province, China |
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Abstract: | BACKGROUNDPelvic lipomatosis (PL) is a rare benign condition with characteristic overgrowth of histologically benign fat and invasion and compression of pelvic organs, often leading to non-specific lower urinary tract symptoms (LUTS). Approximately 40% of patients with PL have cystitis glandularis (CG). The cause of PL combined with CG is poorly understood, and there is currently no effective treatment. Refractory CG with upper urinary tract obstruction even requires partial or radical bladder resection. CASE SUMMARYIn this case, a patient suffering from PL with CG was treated by transurethral resection of bladder tumour (TUR-BT) and oral administration of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor. The LUTS were alleviated, and the cystoscopy results improved significantly. Immunohistochemistry showed up-regulated COX-2 expression in the epithelium of TUR-BT samples, suggesting that COX-2 may participate in the pathophysiological process of PL combined with CG. CONCLUSIONWe report for the first time that celecoxib may be an effective treatment strategy for PL combined with refractory CG. |
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Keywords: | Pelvic lipomatosis Cystitis glandularis Cyclooxygenase-2 Celecoxib Lower urinary tract symptoms Case report |
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