血栓前状态分子标志物变化在不稳定型心绞痛合并高血压诊断中的价值

目的 评价血栓前状态（PTS）分子标志物变化在不稳定型心绞痛合并高血压患者诊断中的价值。方法 回顾分析2018年2月~2019年2月在我院诊治的102例不稳定型心绞痛患者临床资料，依据是否合并高血压分组，将未合并高血压40例设为观察组，合并高血压62例设为对照组，另选取同期在我院体检的40例健康体检者为正常组，分别检测PTS分子标志物，比较三组PTS分子标志物血管性血友病因子抗原（vWF）、血小板α颗粒膜蛋白-140（GMP-140）、组织型纤溶酶原激活剂（t-PA）、血浆纤维蛋白原（Fbg）、纤溶酶原激活抑制物-1（PAI-1）、抗凝血酶（AT）]水平，分析各指标与不稳定型心绞痛的相关性。结果 观察组vWF、GMP-140、Fbg、PAI-1水平均高于正常组，低于对照组（P＜0.05）；观察组AT水平、t-PA活性均低于正常组，高于对照组（P＜0.05）；不稳定型心绞痛患者收缩压和舒张压与年龄、PTS分子标志物（vWF、GMP-140、Fbg、PAI-1、AT、t-PA）水平密切相关（P＜0.05）。结论 不稳定型心绞痛患者存在PTS，合并高血压患者PTS变化比单纯不稳定型心绞痛更明显。

Value of Molecular Marker Changes in Prethrombotic State in the Diagnosis of Unstable Angina Pectoris Complicated with Hypertension

Objective To evaluate the value of changes in molecular markers of prethrombotic state (PTS) in the diagnosis of unstable angina pectoris complicated by hypertension. Methods The clinical data of 102 patients with unstable angina pectoris diagnosed and treated in our hospital from February 2018 to February 2019 were retrospectively analyzed. Based on whether or not hypertension was grouped, 40 cases without hypertension were set as the observation group and 62 cases with hypertension. Set as the control group, and select 40 healthy people who have undergone physical examination in our hospital during the same period as the normal group, and detect the PTS molecular markers respectively, and compare the three groups of PTS molecular markers vascular hemophilia factor antigen (vWF), platelet alpha Granular membrane protein-140 (GMP-140), tissue-type plasminogen activator (t-PA), plasma fibrinogen (Fbg), plasminogen activation inhibitor-1 (PAI-1), anticoagulation blood enzyme (AT)] levels, and analyzed the correlation between each index and patients with unstable angina pectoris.Results The levels of vWF, GMP-140, Fbg, and PAI-1 in the observation group were higher than those in the normal group and lower than those in the control group (P<0.05); AT levels and t-PA activities in the observation group were lower than those in the normal group,higher than the control group(P<0.05); systolic and diastolic blood pressure and age, PTS molecular markers (vWF, GMP-140, Fbg, PAI-1, AT, t -PA) levels were closely related (P<0.05).Conclusion Prethrombotic state exists in patients with unstable angina pectoris, and PTS changes in patients with hypertension are more obvious than those in patients with unstable angina pectoris.