1999-2018年贵州省黔南州居民骨肉瘤发病特征及变化趋势分析

目的 分析1999-2018年黔南州居民骨肉瘤发病特征及变化趋势，为制定防治措施提供参考依据。方法 提取黔南州肿瘤登记处系统中1999-2018年新发骨肉瘤病例发病信息进行性别、年龄分析，计算发病率、中国标化发病率（中标率）、世界标化发病率（世标率）、年龄别发病率和年均变化百分比（APC）等。并对黔南州不同民族骨肉瘤患者病理类型分布特征进行统计分析。结果 1999-2018年黔南州居民新发骨肉瘤237例（男性147例，女性90例），发病率为3.66/100万（男性4.39/100万，女性2.87/100万），中标率2.49/100万（男性2.76/100万，女性2.17/100万），世标率为2.90/100万（男性3.45/100万，女性2.35/100万）。发病率在9岁以前处于较低水平，9岁以后迅速升高，10～19岁年龄段达到峰值14.97/100万（男性16.03/100万，女性12.85/100万），20岁以后迅速下降，60岁以上年龄段发病率逐渐减低，男、女年龄别发病率变化趋势基本一致。237例骨肉瘤患者病理诊断主要以常规性骨肉瘤最为常见，占83.54%。布依族骨肉瘤患者病理类型分布与苗族、水族、毛南族、汉族及其他民族骨肉瘤患者比较，差异均有统计学意义（x2值分别为16.125、14.709、12.486、9.613、10.078、28.727，P=0.001）。结论 贵州省黔南州居民20年来骨肉瘤发病率有呈上升趋势，男性、10～29岁年龄段和布依族居民是防治的重点人群。

Incidence trends and characteristics of osteosarcoma in Qiannan area of Guizhou Province, 1999-2018

To analyze the incidence trends and describe the characteristics of osteosarcoma among residents in Qiannan area of Guizhou Province from 1999 to 2018，and to provide basis for taking control measures and strategies for prevention. Methods Medical information of the cases diagnosed as osteosarcoma ( ICD: C40 and C41) from 1999 to 2018 in Qiannan area of Guizhou Province was extracted from population － based database of Qiannan Cancer Ｒegistry. The incidence rate，Chinese population standardized incidence ( CPSI) ，world population standardized incidence ( WPSI) ，age － sex incidence，and annual percentage change ( APC) were calculated. Ｒesults A total of 237 cases ( male 147，female 90) were diagnosed as osteosarcoma during the study period and the incidence rate was 3. 66 /106( male 4. 39 /106，female 2. 87 /106) ，the CPSI was 2. 49 /106( male 2. 76 /106，female 2. 17 /106) and the WPS Iwas 2. 90 /106( male 3. 45 /106，female 2. 357 /106) ，respectively. The incidence was low before 9 years old，raised rapidly after age 9 years old. The peak of incidence rate of the female ( 16. 03 per 106 person － year) and male( 12. 85 per 106 person － year) was 10 － 19 years old，and then it started to go down 20 years old and the incidence of over 60 years old was decreasing. The trend of incidence of osteosarcoma in male and female was similar in all age groups. Aases were pathologically diagnosed. Among them，conventional osteosarcoma was themost common subtype， which accounted for 83. 54% . There was significant difference between the distribution of histopathological and pathological types of osteosarcoma in Buyi nationality，Miao nationality，Shui nationality，Maonan nationality，Han nationality and other nationality( χ2 = 16. 125，14. 709，12. 486，9. 613，10. 078，28. 727，respectively，P =0. 001) . Conclusion The incidence of osteosarcoma remarkably increases in Qiannan area of Guizhou Province during 1999 －2018. Male，10 － 29 years old and Buyi nationality residents are the key population for prevention and control.