| 普萘洛尔治疗婴儿血管瘤的研究进展 |
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| 引用本文： | 姜集聪,吴建洺,高宇.普萘洛尔治疗婴儿血管瘤的研究进展[J].中华皮肤科杂志,2020,53(7):573-576. |
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| 作者姓名： | 姜集聪 吴建洺 高宇 |
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| 作者单位： | 1. 温州医科大学附属第二医院2. 温州医学院附属第二医院皮肤科 |
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| 摘 要： | 【摘要】 普萘洛尔是非选择性β肾上腺素受体阻滞剂，多项研究已证实其治疗婴儿血管瘤安全有效，作用机制主要包括：①由周细胞介导的血流动力学改变及后续效应；②阻滞血管瘤来源的内皮细胞和干细胞的细胞周期进程从而抑制其增殖，诱导血管瘤来源的内皮细胞凋亡和血管瘤来源的干细胞向脂肪细胞分化；③抑制内皮祖细胞的募集；④降低促血管生成因子（如血管内皮生长因子、基质金属蛋白酶等）的水平。
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| 关 键 词： | 血管瘤 婴儿 普萘洛尔 血流动力学 内皮细胞 血管内皮生长因子类 基质金属蛋白酶类 |
| 收稿时间： | 2019-10-31 |
Propranolol for the treatment of infantile hemangioma |
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| Ji cong Jiang Jianming Wu.Propranolol for the treatment of infantile hemangioma[J].Chinese Journal of Dermatology,2020,53(7):573-576. |
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| Authors: | Ji cong Jiang Jianming Wu |
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| Abstract: | 【Abstract】 Propranolol is a non-selective β-adrenoceptor blocker. Various studies have confirmed that it is safe and effective for the treatment of infantile hemangioma. The mechanism of action mainly includes: （1） pericyte-mediated hemodynamic changes and subsequent effects; （2） inhibiting proliferation of hemangioma-derived endothelial cells and stem cells by blocking cell cycle progression, inducing apoptosis of hemangioma-derived endothelial cells and differentiation of hemangioma-derived stem cells into adipocytes; （3） inhibiting the recruitment of endothelial progenitor cells; （4） reducing levels of pro-angiogenic factors, such as vascular endothelial growth factor, matrix metalloproteinase, etc. |
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| Keywords: | Hemangioma Infant Propranolol Hemodynamics Endothelial cells Vascular endothelial growth factors Matrix metalloproteinases |
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