柯萨奇病毒感染和1型糖尿病的风险关系Meta分析

目的 系统评价柯萨奇病毒感染与1型糖尿病(type 1 diabetes mellitus,T1DM)的风险关系.方法 按照PICOs原则构建检索问题,使用主题词和自由词全面检索Pubmed、EmBase、SinoMed、中国知网、万方数据库、维普网.检索时间自建库至2020年5月28日.使用Newcastle Ott...

Meta-analysis of the relationship between Coxsackie virus infection and the risk of type 1 diabetes

ObjectiveTo systematically evaluate the risk relationship between Coxsackie virus(CV) infection and type 1 diabetes mellitus(T1DM). MethodsAccording to the principle of PICOs, the retrieval scheme was constructed, and PubMed, EmBase, Sinomed, CNKI, Wanfang database, and VIP were searched comprehensively with subject words and free words from the inception until May 28 2020. Newcastle Ottawa scale was used to evaluate the quality of included documents; Revman 5.3 software package was used to draw forest map and funnel map. The odds ratio(or) and 95% confidence interval(CI) were calculated by random effect model(I2>50%) or fixed effect model(I2<50%). The evaluation results included the risk relationship of CV, subtypes(1-6) and type 1 diabetes, and the influence of different study areas, different age and different CV detection methods on the risk relationship of CV and T1DM. ResultsAccording to the inclusion and exclusion criteria, 372 articles were retrieved. Of them, 312 papers that were not related to the research topic were excluded, and 36 papers that were not rigorously designed were excluded after browsing the full text. Finally, 24 literature was selected for systematic evaluation and meta-analysis, one of which had no data available. The total sample size was 3 163, including 1 693 in case group and 1 613 in control group. The results showed that the risk of CVB infection in T1DM patients was 5 times higher than that in the control group(OR=4.49, 95%CI:2.65-7.50, P＜0.05). The risk of CVB infection in T1DM patients was 1.56 times higher than that in the control group(OR=1.56,95%CI:1.20-2.03, P＜0.05). The detection method of CVB had a great influence on the results. ConclusionThe present evidence suggests that CVB infection has a statistical correlation with T1DM. Therefore, CVB infection may be a cause of T1DM or promote the occurrence of T1DM.