| 同型半胱氨酸与癫痫关系的研究进展 |
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| 引用本文： | 沈新月,石郑浩,侯一玮,葛汝丽,王美玲. 同型半胱氨酸与癫痫关系的研究进展[J]. 滨州医学院学报, 2020, 43(2): 149-151. DOI: 10.19739/j.cnki.issn1001-9510.2020.02.017 |
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| 作者姓名： | 沈新月 石郑浩 侯一玮 葛汝丽 王美玲 |
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| 作者单位： | 1 滨州医学院临床医学院 山东 烟台 264003;2 滨州医学院附属医院神经内科 |
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| 基金项目： | 山东省医药卫生发展计划(2018WSB30004);滨州市科技发展计划(2014ZC0144) |
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| 摘 要： | 同型半胱氨酸(Hcy)是甲硫氨酸代谢的中间产物。Hcy不仅是心血管疾病的独立危险因素,还与神经系统疾病如癫痫、中风、认知障碍、帕金森病和阿尔茨海默病有关。癫痫是常见的神经系统疾病之一,具有发作性、短暂性、重复性、刻板性的特点。研究表明,严重高同型半胱氨酸(HHcy)血症可引起癫痫发作并增加癫痫的发作频率。目前关于HHcy血症与癫痫发作国内相关研究罕见。本文主要阐述HHcy血症、NMDA受体与癫痫之间的关系以进一步探讨癫痫的发病机制,以提供新的临床治疗方法。
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| 关 键 词： | 同型半胱氨酸 癫痫 NMDA受体 |
| 收稿时间： | 2019-06-28 |
Research progress on the interactions between homocysteine and epilepsy |
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| SHEN Xinyue,SHI Zhenghao,HOU Yiwei,GE Ruli,WANG Meiling. Research progress on the interactions between homocysteine and epilepsy[J]. Journal of Binzhou Medical College, 2020, 43(2): 149-151. DOI: 10.19739/j.cnki.issn1001-9510.2020.02.017 |
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| Authors: | SHEN Xinyue SHI Zhenghao HOU Yiwei GE Ruli WANG Meiling |
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| Affiliation: | 1.School of Clinical Medicine, Binzhou Medical University, Yantai 264003, Shandong, P.R.China;2.Department of Neurology, Binzhou Medical University Hospital |
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| Abstract: | Homocysteine is formed as an intermediate during methionine metabolism. Hcy is known to be an independent risk factor for cardiovascular disease and neurological diseases including epilepsy, stroke, cognitive disorders, Parkinson's disease and Alzheimer's disease. Epilepsy is one of the common diseases of neurology, and it has characteristics of episodic, transient, repetitive and stereotypic. One research has shown that severe hyperhomocysteinemia causes seizures and increases the frequency of seizures. But the interactions between hyperhomocysteinemia and seizures are rare reported in China. This review focuses on the interactions among homocysteinemia, NMDA receptors and epilepsy to further explore the pathogenesis of epilepsy and provides new clinical treatments. |
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| Keywords: | homocysteine epilepsy N-methyl-D-aspartic acid receptor |
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