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肝硬化患者的视网膜血管特征及其可能的诊断价值
引用本文:黄茜,钟跃思,蔡满航. 肝硬化患者的视网膜血管特征及其可能的诊断价值[J]. 新医学, 2021, 52(4): 255-259. DOI: 10.3969/j.issn.0253-9802.2021.04.006
作者姓名:黄茜  钟跃思  蔡满航
作者单位:510630 广州,中山大学附属第三医院肝胆外科
基金项目:国家自然科学基金(81470860)
摘    要:目的分析肝硬化患者的视网膜血管特征,并探讨视网膜血管参数在肝硬化中的诊断价值和眼底检查作为肝硬化筛查手段的可行性。方法将90例确诊为肝硬化的患者和93名同期体检健康人员分别设为肝硬化组与对照组。使用眼底照相机和自动化图像分析系统对入组个体进行眼底图像采集和视网膜血管参数测量,包括视网膜血管管径、血管弯曲度、血管分支夹角和血管分形维数。比较2组各视网膜血管参数,采用受试者工作特征(ROC)曲线分析各视网膜参数单独和联合诊断肝硬化的效能。结果与对照组相比,肝硬化组具有更宽的视网膜血管管径、更大的血管分支夹角和更小的血管分形维数(P均<0.05)。视网膜血管管径、视网膜血管分形维数及两者联合诊断肝硬化的ROC曲线下面积分别为0.869(95%CI 0.820~0.919)、0.780(95%CI0.713~0.847)和0.901(95%CI 0.860~0.942)。结论肝硬化患者的视网膜血管系统发生了明显改变。视网膜血管管径和血管分形维数对肝硬化具有一定的诊断价值,诊断效能较佳,两者联合具有更高的诊断价值。眼底检查或可为肝硬化的便捷筛查和无创诊断带来更多的可能性。

关 键 词:肝硬化  诊断  视网膜血管管径  视网膜血管分形维数  眼底检查
收稿时间:2020-10-20

Retinal vascular features and diagnostic values in patients with liver cirrhosis
Huang Xi,Zhong Yuesi,Cai Manhang. Retinal vascular features and diagnostic values in patients with liver cirrhosis[J]. New Chinese Medicine, 2021, 52(4): 255-259. DOI: 10.3969/j.issn.0253-9802.2021.04.006
Authors:Huang Xi  Zhong Yuesi  Cai Manhang
Affiliation:Department of Hepatobiliary Surgery, the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630, China
Abstract:Objective To analyze the retinal vascular features of patients with liver cirrhosis, investigate the diagnostic value of retinal vascular parameters for liver cirrhosis, and to evaluate the possibility of utilizing fundus examination as a screening method for liver cirrhosis. Methods Ninety liver cirrhosis patients (liver cirrhosis group) and 93 healthy subjects (control group) were enrolled. The funsus images and retinal vascular parameters including retinal vascular caliber, retinal vascular tortuosity, retinal vascular branching angle and retinal vascular fractal dimension were measured by fundus examination and automated image analysis system. The retinal vascular parameters were statistically compared between two groups. The diagnostic efficiency of single and combined retinal vascular parameters for liver cirrhosis was evaluated by the ROC curve. Results Compared with the control group, the retinal vascular caliber and the retinal vascular branching angle were significantly higher in the cirrhosis group (both P < 0.05). The area under ROC curve for retinal vascular caliber, retinal vascular fractal dimension and the two combined in the diagnosis of liver cirrhosis was 0.869 (95%CI 0.820-0.919), 0.780 (95%CI 0.713-0.847) and 0.901 (95%CI 0.860-0.942), respectively. Conclusions Significant changes in retinal vasculature were found in patients with liver cirrhosis. The retinal vascular caliber and the retinal vascular fractal dimension are of certain value in the diagnosis of liver cirrhosis with relatively high diagnostic efficiency, and the combination of these two retinal vascular parameters yields better diagnostic value. The fundus examination is considered as a potential convenient and non-invasive screening tool for liver cirrhosis.
Keywords:Liver cirrhosis  Diagnosis  Retinal vascular caliber  Retinal vascular fractal dimension  Fundus examination  
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