分段毛囊移植治疗毛发部位白癜风

【摘要】 目的 探讨分段毛囊移植治疗特殊部位白癜风的疗效。方法 2016年12月至2018年12月在杭州市第三人民医院皮肤科纳入10例19 ~ 28岁稳定期白癜风患者（男4例,女6例）,共26处白斑合并白发,其中18处为头皮,8处为眉部。采用毛囊单位提取法从枕部或耳后区域获取毛囊,并均分为上下两部分。患者每处白斑合并白发皮损分为2部分,上下两部分毛囊分别移植于白斑的不同区域。术后每4周随访1次,观察复色及毛发生长情况。结果 12周时,移植毛囊上部26处白斑中痊愈3处,显效5处,好转12处,无效6处,有效率30.8%（8/26）,且均未见毛发生长;移植毛囊下部的26处皮损中痊愈5例,显效7例,好转11例,无效3例,有效率46.2%（12/26）,8处皮损出现毛发生长。移植毛囊上部组与移植毛囊下部组有效率差异无统计学意义（χ2 = 1.30,P = 0.25）。结论 分段毛囊移植术适用于头皮和眉部白癜风合并白发的治疗。

Sectioned hair follicle transplantation for the treatment of stable vitiligo in hair-bearing areas

【Abstract】 Objective To evaluate the efficacy of sectioned hair follicle transplantation in the treatment of stable vitiligo in hair-bearing areas. Methods A total of 10 patients with stable vitiligo aged 19 - 28 years （including 4 males and 6 females） were enrolled from Department of Dermatology, The Third People′s Hospital of Hangzhou between December 2016 and December 2018. Among the 10 patients, a total of 26 white patches accompanied by leukotrichia received sectioned hair follicle transplantation, including 18 on the scalp and 8 on the eyebrow. Hair follicles were obtained from the occipital and postauricular regions by follicular unit extraction, and divided into the upper and lower portions. Each white patch with leukotrichia was divided into 2 regions, and the 2 portions of the hair follicle were transplanted into the 2 regions of lesions respectively. The patients were followed up once every 4 weeks after grafting, and repigmentation and hair growth were evaluated. Results At 12 weeks, of the 26 white patches transplanted with the upper hair follicles, 3 were cured, 5 were markedly improved, 12 were improved, and 6 showed no response; the response rate was 30.8%（8/26）, and no hair grew on the transplantation sites. Of the 26 lesions transplanted with the lower hair follicles, 5 were cured, 7 were markedly improved, 11 were improved, and 3 showed no response; the response rate was 46.2% （12/26）, and hair growth was observed on 8 lesions. There was no significant difference in the response rate between the upper hair follicle transplantation group and lower hair follicle transplantation group （χ2 = 1.30, P = 0.25）. Conclusion Sectioned hair follicle transplantation is suitable for the treatment of vitiligo complicated by leukotrichia on the scalp and eyebrow.