T2*mapping辅助MRI技术对差异性膝关节骨性关节炎软骨损伤程度的诊断价值

目的探讨T2*mapping辅助MRI技术对差异性膝关节骨性关节炎软骨损伤程度的诊断价值。方法选取我院2016年6月~2019年6月收治的膝关节骨性关节炎患者作为病变组，共46例，其中男性32例，女性14例，年龄22~69岁(41.19±15.53岁)；另将7名健康志愿者作为对照组，其中男性5例，女性2例，年龄23~64岁(42.05±15.28岁)。两组均行膝关节MRI常规扫描及T2*mapping序列扫描，分别比较两组不同区域软骨T2*值，分析病变组软骨损伤程度、各区域浅深层软骨以及股骨内侧髁、外侧髁负重区与非负重区的T2*值。结果病变组股骨内侧髁、股骨外侧髁、内侧胫骨平台、外侧胫骨平台T2*值均高于对照组(P < 0.05)。重度患者股骨内侧髁、股骨外侧髁、内侧胫骨平台、外侧胫骨平台T2*值均高于轻度患者(P < 0.05)。病变组股骨内侧髁、股骨外侧髁、内侧胫骨平台、外侧胫骨平台浅层软骨的T2*值均高于深层软骨(P < 0.05)。病变组股骨内侧髁、外侧髁负重区的T2*值均高于负重区(P < 0.05)。结论T2*mapping辅助MRI技术在诊断差异性膝关节骨性关节炎软骨损伤程度中具有较高的价值，可为患者病情的判断提供可靠依据。 

Diagnostic value of T2* mapping-assisted MRI in patients with different degree of OA cartilage injury of knee joint

ObjectiveTo evaluate the diagnostic value of T2* mapping-assisted magnetic resonance imaging (MRI) in patients with different degree of OA cartilage injury of knee joint.MethodsA total of 46 patients with knee OA admitted to our hospital from June 2016 to June 2019 were selected as pathological group. There were 32 males and 14 females in pathological group, with the age from 22-69 years old (41.19 ± 15.53). Another 7 healthy volunteers were taken as the control group, including 5 males and 2 females with the age from 23 to 64 years old (42.05±15.28). Two groups underwent routine MRI and T2* mapping sequence scans of the knee. The T2* values of cartilage in different areas were compared. In addition, T2* values in the loading zone and non-loading zone of the medial and lateral condyles of the femur were analyzed for the patients in the lesion group with different degree of cartilage damage, shallow and deep cartilage in each region.ResultsThe T2* values of medial femoral condyle, lateral femoral condyle, medial tibial plateau and lateral tibial plateau in the lesion group were significantly higher than those in the control group (P < 0.05). The T2* values of medial femoral condyle, lateral femoral condyle, medial tibial plateau and lateral tibial plateau in the severe group were significantly higher than those in the mild group (P < 0.05). The T2* values of the medial femoral condyle, the lateral femoral condyle, the medial tibial plateau and the superficial cartilage of the lateral tibial plateau in the lesion group were significantly higher than those in the deep cartilage (P < 0.05). The T2* values in the loading zone of medial femoral condyle and lateral condyle in the lesion group were significantly higher than that in the loading zone (P < 0.05).ConclusionT2* mapping-assisted MRI has a high value in the diagnosis of patients with different degree of OA cartilage injury of knee joint. It can provide reliable basis for the judgment of patients' conditions.