卵巢癌合并阴道炎患者阴道微生态特征及其影响因素分析

目的分析卵巢癌合并阴道炎患者的阴道微生态特征及影响因素，为临床预防及治疗提供参考。 方法选取卵巢癌患者330例，分析合并阴道炎患者感染率及阴道微生态特征。根据是否合并阴道炎将患者分为感染组和非感染组，比较2组年龄、文化程度、基础疾病、避孕套使用、性生活频率、化疗、自行阴道冲洗、阴道炎史。采用多因素Logistic回归分析确定卵巢癌合并阴道炎的影响因素。 结果330例卵巢癌患者中合并阴道炎117例（35.45%）。117例患者中感染类型占比前三为阴道假丝酵母菌病（vulvovaginal candidiasis,VVC）35例（29.91%）、细菌性阴道炎（bacterial vaginosis，BV）30例（25.64%）、微生态失调28例（23.93%）。感染组年龄≥50岁、有基础疾病、性生活频率≥2次/周、化疗、自行阴道冲洗、阴道炎史比例高于非感染组，文化程度专科以上、使用避孕套比例低于非感染组，差异有统计学意义（P＜0.05）。Logistic回归分析结果显示，年龄≥50岁、基础疾病、性生活频率≥2次/周、化疗、自行阴道冲洗、阴道炎史是卵巢癌合并阴道炎的危险因素（P＜0.05）,文化程度专科以上、使用避孕套是卵巢癌合并阴道炎的保护因素（P＜0.05）。 结论卵巢癌合并阴道炎患者以VVC为主，BV次之。年龄、基础疾病、性生活频率、化疗是卵巢癌合并阴道炎的危险因素，文化程度专科以上、使用避孕套是卵巢癌合并阴道炎的保护因素。临床应依据感染特征及危险因素，纠正危险因素涉及的不良生活习惯，加强生理健康知识及疾病预防知识的普及。

Analysis of vaginal microecological characteristics and influencing factors in ovarian cancer patients with vaginitis

ObjectiveTo analyze the vaginal microecological characteristics and influencing factors of patients with ovarian cancer complicated with vaginitis, thereby providing reference for clinical prevention and treatment.MethodsA total of 330 ovarian cancer patients admitted were selected. The infection rate and vaginal microecological characteristics of patients with vaginitis were analyzed. Patients were divided into infection group and non-infection group according to presence or absence of vaginitis. Age, education level, underlying diseases, condom use, sexual frequency, chemotherapy, self-vaginal irrigation and history of vaginitis were compared between the two groups. Multivariate Logistic regression analysis was used to determine the influencing factors of ovarian cancer with vaginitis.ResultsOf 330 patients with ovarian cancer,117(35.45%) were complicated with vaginitis. The top three infection types in 117 patients were vaginal candidiasis(VVC) in 35 cases(29.91%). bacterial vaginosis(BV) in 30 cases(25.64%) and microecological disorders in 28 cases(23.93%). Age ≥50 years, underlying diseases, frequency of sexual life ≥2 times/week, chemotherapy, self-vaginal irrigation and history of vaginitis were higher in infection group than in non-infection group, while junior college education or higher and condom use ratio were lower in infection group than in non-infection group, suggesting significant difference(P＜0.05). Logistic regression analysis showed that age ≥50 years, underlying diseases, frequency of sexual life≥2 times/week, chemotherapy, self-vaginal irrigation and history of vaginitis were the risk factors of ovarian cancer complicated with vaginitis(P＜0.05). Junior college education or higher and condom use were the protective factors of ovarian cancer complicated with vaginitis(P＜0.05).ConclusionOvarian cancer patients with vaginitis mainly had VVC, followed by BV. Age, underlying diseases, frequency of sexual life and chemotherapy are the risk factors of ovarian cancer complicated with vaginitis. Junior college education and condom use are the protective factors of ovarian cancer complicated with vaginitis. In clinical practice, according to the characteristics of infection and risk factors, we should correct the poor living habits related to risk factors and strengthen the popularization of knowledge on physiological health and disease prevention.