参麦注射液促进子宫切除术后骨骼肌功能恢复

目的：观察参麦注射液预处理对腹腔镜子宫切除术患者腹腔引流液细胞因子及骨骼肌功能的影响。方法：将66例拟行腹腔镜下子宫切除术患者随机分为对照组（C组）和参麦组（SM组），SM组于切皮前静脉滴注参麦注射液0.6 mL/kg，C组给予等量0.9%氯化钠溶液。测定术前、术后4 h、术后1 d、术后2 d握力、肌耐力，以及腹腔引流液中炎症因子水平，评估术后恶心、呕吐等不良反应情况。结果：两组患者握力和肌耐力术后与术前比较均明显降低，SM组较C组各时间点降低幅度明显减小（P＜0.01）；术后4 h SM组腹腔引流液中IL-6和TNF-α水平均低于C组（P＜0.05），引流液中IL-6水平与肌耐力呈负相关（P＜0.05）。两组恶心、呕吐等不良反应发生率差异无统计学意义（P＞0.05）。结论：参麦注射液0.6 mL/kg预处理可通过减少炎症因子的产生，促进腹腔镜子宫切除术后患者骨骼肌功能的恢复。

Promotion of romotes skeletal muscle function recovery in hysterectomy patients by Shenmai injection

Objective: To investigate the effect of Shenmai injection pretreatment on the levels of cytokines in abdominal drainage and skeletal muscle function in patients undergoing laparoscopic hysterectomy. Methods: Sixty-six patients undergoing laparoscopic hysterectomy were randomly divided as the control group (C group) and the Shenmai group (SM group). The patients in SM group received intravenous administration of Shenmai injection 0.6 mL/kg before skin incision, while the same amount of saline was given instead in C Group. The grip strength, muscle endurance, and inflammatory cytokines levels in abdominal drainage fluid were measured before surgery as baselines and 4 h, 1, 2 days post-operation as well. The occurrence of nausea, vomiting and other adverse events were also documented. Results: Compared with C group, the declines in grip strength and muscle endurance in SM group were significantly attenuated in each time point (P<0.05). However, grip strength and muscle endurance were decreased in both groups, compared with baseline values (P<0.05). The levels of IL-6 and TNF-α in the abdominal drainage fluid of SM group at 4 hours post-operation were significantly lower than those of group C (P<0.05), and the level of IL-6 in the drainage fluid was negatively correlated with grip work (P<0.05). There was no significant difference in adverse events between the the groups (P>0.05). Conclusion: Pretreatment with Shenmai injection 0.6 mL/kg could reduce the production of inflammatory cytokines and thus promote the recovery of skeletal muscle function in patients undergoing laparoscopic hysterectomy.