5-羟色胺受体在帕金森病治疗中的应用前景

帕金森病(Parkinson's disease,PD)是世界上常见的神经退行性疾病,严重危害中老年人健康,给家庭和社会带来沉重负担.PD的病理学特征为黑质纹状体内多巴胺含量减少,进而导致运动迟缓和肌强直等运动症状,但PD的发病机制尚不明确.研究表明5-羟色胺(5-HT)受体可能参与PD的发病机制.本文回顾5-HT受体...

Therapeutic prospect of 5-HT receptors in Parkinson's disease

Parkinson's disease (PD) is a very common degenerative disease,it endangers the health of middle-aged and aged people and brings a heavy burden to families and society.The principal pathophysiology of PD is the reduction of dopamine in the substantia nigra pars compacta and striatum,and consequent motor bradykinesia and rigidity motor symptoms.However,the exact pathogenesis of PD is not clear yet.Evidence indicate that serotonin (5-HT) receptors may be involved in the pathogenesis of PD.This review comments the relationship of the main 5-HT receptors and PD.Further,5-HT1A,5-HT1B/D receptors are associated with dyskinesia induced by L-DOPA.5-HT2A receptor is associated with motor and non-motor symptoms.5-HT2C receptor has anti-PD effect.5-HT4 receptor is associated with dopamine release and non-motor symptom.The selective receptor medicine and more studies to explore the therapeutic prospect of 5-HT receptors in PD treatment is absolutely necessary in the future.