HPV16/18与喉鳞状细胞癌发生发展的关系

目的：研究喉鳞状细胞癌的发生与HPV16／18的相关性。方法：采用原位杂交法检测54例喉癌中HPV16／18的表达。结果：54例喉癌组织中30例HPV16／18阳性，喉癌组HPV16／18的阳性表达为55．6％，癌旁不典型增生组为38．1％，二者比较有显著性差异（P〈0．05）；HPV16／18在癌周正常组织、癌旁单纯增生及轻度不典型增生组织中无表达。随着不典型增生程度的增大，HPV16／18阳性表达率增高，轻、中、重度增生分别为0％、7．1％和12．5％；HPV16／18的表达与喉癌的分化程度及有无淋巴结转移无关（P〉0．05）。结论：HPV16／18与喉癌的发生有关，与喉癌的分化程度及有无淋巴结转移无关。

PATHOGENIC RELATION BETWEEN HPV16/18 AND LARYNGEAL SQUAMOUS CELL CARCINOMA

Objective: To study the pathogenic relation between human papilloma virus and laryngeal squamous cell carcinomas.Methods: In situ hybridization method was used in 54 cases of laryngeal carcinoma.[WTHZ]Results: In 54 cases of laryngeal carcinoma,30 cases showed HPV16/18 expression. The frequency of HPV16/18 expression in laryngeal carcinoma and hyperplasia were 55.6% and 38.1% respectively($P$<0.05).There was no expression of HPV16/18 in normal laryngeal mucosa,simple hyperplasia and mild atypical hyperplasia,There was high expression of HPV16/18 with progressing of atypical hyperplasia.The frequency of HPV16/18 expression of mild atypical hyperplasia was 0%,medium atypical hyperplasia was 7.1% and serious atypical hyperplasia was 12.5%;and there was no relation with differentiation and lymph node metastasis($P$>0.05).Conclusion: The pathogenesis of laryngeal squamous cell carcinoma is closely related with HPV16/18 infection.There was no relation with differentiation and lymph node metastasis.