| 癌症患者血浆PAI-1浓度变化 |
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| 引用本文： | 王宇,肖英红,何成彦,王楠,冯学超.癌症患者血浆PAI-1浓度变化[J].中国实验诊断学,2010,14(4):536-537. |
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| 作者姓名： | 王宇 肖英红 何成彦 王楠 冯学超 |
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| 作者单位： | 1. 东北师范大学膜通道实验室,吉林,长春,130024
2. 吉林大学中日联谊医院,吉林,长春,130033 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的测定多种恶性肿瘤患者血浆中纤溶酶原激活物抑制剂1(Plasminogen activator inhibitor-1,PAI-1)浓度变化情况,探讨PAI-1血浆含量变化作为恶性肿瘤诊断中的作用。方法收集乳腺癌、肺癌、喉癌血液标本各40例,并以正常人血液标本作对照,用ELISA法检测肿瘤患者及正常对照组血浆中PAI-1的含量,并比较其差异。结果与正常对照组(9.84±4.66 ng/ml)相比,乳腺癌(21.49±10.54 ng/ml),肺癌(15.10±8.55 ng/ml),喉癌(14.03±7.14 ng/ml)患者血浆中PAI-1含量均明显升高,其中乳腺癌组与正常组相比差异极为显著(P0.01)。结论血浆中PAI-1的浓度升高可作为肿瘤诊断辅助指标,PAI-1可作为肿瘤治疗潜在靶位。
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| 关 键 词： | 纤溶酶原激活物抑制剂1 癌症 血浆 标志物 |
The plasma level of PAI-1 in normal group and cancer groups |
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| WANG Yu,XIAO Ying-hong,HE Cheng-yan,et al..The plasma level of PAI-1 in normal group and cancer groups[J].Chinese Journal of Laboratory Diagnosis,2010,14(4):536-537. |
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| Authors: | WANG Yu XIAO Ying-hong HE Cheng-yan |
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| Institution: | WANG Yu1,XIAO Ying-hong1,HE Cheng-yan2,et al.(1.Membrane Channel Research Lab,Northeast Normal University,Changchun 130024,China,2.China-Japan Union Hospital of Jilin University,Changchun 130033,China) |
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| Abstract: | Objective to explore the variation of PAI-1 concentration in blood plasma between normal group and cancer groups. Methods assay the plasma PAI-1 level in both cancer groups and normal group by ELISA. Results PAI-1 levels in plasma of breast cancer groups（21.49±10.54 ng/ml）, lung breast cancer groups（ 15.10 ± 8.55 ng/ml） and larynx cancer groups （14.03 ± 7.14 ng/ml）were higher than that of normal group（9.84 ±4.66 ng/ml）, particularly, the PAI-1 concentration in breast cancer groups significeantly varied （P〈 0. 01 ） to control group. Conclusion PAI -1 maybe can used as a auxiliary marker to detect cancer and PAI-I can be a potential target for tumor therapy. |
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| Keywords: | Plasminogen Activator Inhibitor-1 cancer plasma biomarker |
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