| 甲状腺素对前列腺素（PGE1）免疫抑制作用的拮抗作用 |
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| 引用本文： | 孙汶生 张宝珠. 甲状腺素对前列腺素（PGE1）免疫抑制作用的拮抗作用[J]. 中华内分泌代谢杂志, 1993, 9(2): 105-106 |
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| 作者姓名： | 孙汶生 张宝珠 |
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| 作者单位： | 山东医科大学微生物教研室，山东医科大学微生物教研室，山东医科大学微生物教研室，山东医科大学微生物教研室，山东医科大学微生物教研室，山东医科大学微生物教研室，山东医科大学附属医院 250012，250012，250012，250012，250012，250012 |
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| 摘 要： | 同步检测前列腺素组、甲状腺片拮抗组BALB/C纯系小鼠血清T_3、T_4的水平及相应免疫指标的变化。结果显示甲状腺片(1.2μg/日/g体重)对免疫抑制剂前列腺素E_1(PGE_1 10~(-8)mol/L)具有一定的拮抗作用,发现甲状腺素可逆转前列腺素抑制BALB/c小鼠腹腔渗出巨噬细胞(Mφ)吞噬活性及抗体形成细胞的活性,可明显增高脾脏NK细胞对小鼠腹水型肝癌细胞(Hepa系)的杀伤作用。
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| 关 键 词： | 甲状腺素 前列腺素 免疫调节 小鼠 近交BALB C |
ANTAGONISTIC EFFECT OF THYROXINE ON IMMUNOSUPPRESSIVE REACTION OF PROSTAGLANDIN E_1 |
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| Sun Wen-sheng,et al.. ANTAGONISTIC EFFECT OF THYROXINE ON IMMUNOSUPPRESSIVE REACTION OF PROSTAGLANDIN E_1[J]. Chinese Journal of Endocrinology and Metabolism, 1993, 9(2): 105-106 |
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| Authors: | Sun Wen-sheng et al. |
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| Affiliation: | Sun Wen-sheng,et al.Dept.of Microbiology,Shandong Medical University,Jinan,250012 |
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| Abstract: | The concentrations of serum T3, T4 and relevant immune indices were synchronously detected in BALB/c mice which were devided into prostaglandin-control group and thyroxine-treated group. The results confirmed certain antagonistic effect of small dose of thyroxine (1.2 0g/g per day) on the immunosuppressive reaction of prostaglandin E1 (PGE1 10-3 rnol/L). Thyroxine may reverse the inhibiting effect of PGE1 on the phagocytic activity of macrophages (M ) from the peritoneal permeation of mice and may enhance the activity of antibody-forming cells, as well as the cytotoxic killer effect ot spleen NK cells on the cancer cells (Hcpa line) of mice. |
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| Keywords: | Thyroxine Prostaglandin E_1 Mice inbrid BALE C Antagonism Inununoregulation |
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