Disturbed calcium metabolism in subjects with elevated diastolic blood pressure |
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Authors: | H Reichel R Liebethal H -W Hense H Schmidt-Gayk E Ritz |
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Institution: | (1) GSF/Medis Institut, München-Neuherberg, Germany;(2) Hormonlabor, Heidelberg, Germany;(3) Medizinische Klinik der Universität Heidelberg Sektion Nephrologie, Bergheimer Strasse 56a, W-6900 Heidelberg, Germany |
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Abstract: | Summary Essential hypertension has been associated with disturbed calcium metabolism, but the available data are controversial. We measured parameters of calcium metabolism in groups of untreated male subjects (n = 78) with elevated diastolic blood pressure (101 ± 6 mmHg, mean ± SD) and age-matched male subjects (n=79) with low diastolic blood pressure (62 ± 4 mmHg). The participants of the study were drawn from a random population sample. Subjects with high diastolic blood pressure had significantly higher carboxy-terminal parathyroid hormone (PTH) plasma concentrations than controls with low diastolic blood pressure (median 114 vs. 43 pmol/l, P < 0.01). The 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations were comparable in both groups. Individuals with high diastolic blood pressure had significantly lower total serum calcium (2.41 ± 0.10 vs. 2.47 ± 0.10 mmol/l, mean ± SD; P < 0.01). PTH concentrations were correlated with diastolic pressure (r = –0.39, P < 0.001). The data are compatible with increased parathyroid activity despite unchanged concentrations of vitamin D metabolites in human hypertension.Abbreviations PTH
parathyroid hormone
- C-PTH
carboxy-terminal parathyroid hormone
- 1,25(OH)2D
1,25-di-hydroxyvitamin D
- 25(OH)D
25-hydroxyvitamin D |
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Keywords: | Hypertension Calcium Parathyroid hormone 1 25-Dihydroxyvitamin D3 |
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