Characterisation of the imidazole ring-opened forms of trans-8,9-dihydro-8,9-dihydro-8-(7-guanyl)9-hydroxy aflatoxin B1 |
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| Authors: | P J Hertzog J R Smith R C Garner |
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| Affiliation: | 1Cancer Research Unit, University of York Heslington, York Y01 5DD, UK
2Department of Chemistry, University of York Heslington, York Y01 5DD, UK |
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| Abstract: | Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followedby acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-ylformamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-ylamino)9-hydroxy AFB1. The minor compound converts into the majorisomer in aqueous dimethylsulphoxide. |
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