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Preexisting crescentic glomerulonephritis in the renal allograft
Affiliation:1. Division of Renal Medicine and Baxter Novum, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;2. Kidney Disease Center, 1st Affiliated Hospital College of Medicine, Zhejiang University, Hangzhou, China;3. Division of Medical Imaging and Technology, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;4. Department of Radiology, Karolinska University Hospital, Huddinge, Sweden;5. Division of Transplantation Surgery, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;1. MRC Centre for Transplantation, King''s College London, Great Maze Pond, London SE1 9RT, UK;2. Biostatistics and Health Informatics Department, Institute of Psychiatry, Psychology and Neuroscience, King''s College London, 16 De Crespigny Park, London SE5 8AF, UK;3. NIHR Biomedical Research Centre at Guy''s & St Thomas’ NHS Foundation Trust and King''s College London, Great Maze Pond, London SE1 9RT, UK;4. Guy''s and St Thomas’ NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK;5. Manchester Royal Infirmary, Oxford Rd, Manchester M13 9WL, UK;6. Hull University Teaching Hospitals NHS Trust, Anlaby Rd, Hull HU3 2JZ, UK;7. St James''s University Hospital, Beckett St, Leeds LS9 7TF, UK;8. Department of Immunology, Genetics and Pathology, Uppsala University, Rudbecklaboratoriet, 751 85 Uppsala, Sweden;9. Leicester General Hospital, Gwendolen Rd, Leicester LE5 4PW, UK;10. Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK;11. Salford Royal NHS Foundation Trust, Stott Ln, Salford M6 8HD, UK;12. Queen Alexandra Hospital, Southwick Hill Rd, Cosham, Portsmouth PO6 3LY, UK;13. University of Glasgow, University Avenue, Glasgow G12 8QQ, UK;14. Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London WC1N 3JH, UK;15. University College London Great Ormond Street Institute of Child Health, NIHR Great Ormond Street Hospital Biomedical Research Centre, London WC1N 1EH, UK;p. St George''s Hospital, Blackshaw Rd, London SW17 0QT, UK & Institute of Medical and Biomedical Education, St George''s, University of London, Cranmer Terrace, London SW17 0RE;q. Northern General Hospital, Herries Rd, Sheffield S5 7AU, UK;r. Internal Medicine, Lindenhofgruppe Berne, Switzerland;s. University of Bern, Berne, Switzerland;t. School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK;u. Department of Immunology and imas12 Research Institute, University Hospital 12 de Octubre, Madrid, Spain;v. King''s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK;w. Hospital Universitario Vall d''Hebrón, Passeig de la Vall d''Hebron, 119-129, 08035 Barcelona, Spain;x. Evelina London Children''s Hospital, Westminster Bridge Rd, Lambeth, London SE1 7EH, UK;y. King''s Health Partners, Guy''s Hospital, London SE1 9RT, UK;z. Transplantační laboratoř, Institut klinické a experimentální medicíny (IKEM), Vídeňská 1958/9, 140 21 Praha 4, Czech Republic
Abstract:Two patients who received cadaveric renal transplants from the same donor were found to have similar diffuse proliferative glomerular lesions on renal biopsies performed for delayed graft function. The donor had no known disease, but had subtle abnormalities on preprocurement urinalysis. In retrospect, lupus nephritis is suspected in the donor. The authors detail the course of these 2 patients, review the literature on preexisting glomerular lesions, and address issues with regard to donor selection.
Keywords:Preexisting disease  crescentic glomerulonephritis  renal allograft  0-hour biopsies  1-hour biopsies
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