Enteroviruses and type 1 diabetes mellitus |
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| Affiliation: | 1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia;2. Moscow Institute of Physics and Technology, Department Molecular and Biological Physics, Moscow, Russia;3. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia;4. Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia;1. Post Graduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, PR, Brazil;2. Department of Clinical Analysis, Federal University of Parana, Curitiba, Parana, Brazil |
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| Abstract: | Despite decades of research, the etiology of type 1 diabetes mellitus (DM) is unknown. Several risk factors have been associated with type 1 DM, including viral infections, genetic predisposition, nutritional factors, and chemicals. Several investigators hypothesize that the etiologies of type 1 DM result from a complex interaction of genetic and environmental factors. In this paper we review the epidemiologic data linking enteroviruses to type 1 DM and discuss potential mechanisms of pathogenesis. |
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