| 创新课程药动学-药效学模型实验教学实践 |
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| 引用本文： | 陈琰,张翮,钟延强,邹豪,鲁莹,俞媛,孙治国,高静,邓莉,丁雪鹰.创新课程药动学-药效学模型实验教学实践[J].药学教育,2011,27(3):52-54. |
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| 作者姓名： | 陈琰 张翮 钟延强 邹豪 鲁莹 俞媛 孙治国 高静 邓莉 丁雪鹰 |
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| 作者单位： | 第二军医大学药学院,上海,200433 |
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| 基金项目： | 第二军医大学教学研究与改革项目基金资助;编号JYC2009012 |
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| 摘 要： | 作为药动学扩展的创新课程,首次在药学本科学员中开展药动学-药效学模型实验.选用氟比洛芬作为模型药物,HPLC法测定口服给药后家兔的血药浓度.采用内毒素发热家兔模型,考察氟比洛芬的药动学和药效学参数.与传统药物动力学实验相比,药动学-药效学模型实验是培养学生实践能力和创新能力的实验教学新模式.
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| 关 键 词： | 药动学 药效学 药动-药效模型 氟比洛芬 实验教学 |
Exploration and Practice of the Experimental Teaching of PK-PD Model as an Innovative Course |
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| CHEN Yan,ZHANG He,ZHONG Yan-Qiang,ZOU Hao,LU Ying,YU Yuan,SUN Zhi-Guo,GAO Jing,DENG Li,DING Xue-Ying.Exploration and Practice of the Experimental Teaching of PK-PD Model as an Innovative Course[J].Pharmaceutical Education,2011,27(3):52-54. |
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| Authors: | CHEN Yan ZHANG He ZHONG Yan-Qiang ZOU Hao LU Ying YU Yuan SUN Zhi-Guo GAO Jing DENG Li DING Xue-Ying |
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| Institution: | CHEN Yan,ZHANG He,ZHONG Yan-Qiang,ZOU Hao,LU Ying,YU Yuan,SUN Zhi-Guo,GAO Jing,DENG Li,DING Xue-Ying(School of Pharmacy,Second Military Medical University,Shanghai 200433,China) |
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| Abstract: | As an innovative course of pharmacokinetics' extension,the experimental teaching of pharmacokinetics-pharmacodynamics model is performed for pharmacy students.Flurbiprofen(FP) were chosen as the model drug.A simple HPLC method was establisbed to determine concentrations of FP in rabbit plasma following oral administration.The pharmacokinetics(PK) and pharmacodynamics(PD) of FP were examined simultaneously in rabbits which were febrile caused by endotoxin.Contrast to traditional experimental teaching of PK,t... |
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| Keywords: | Pharmacokinetics Pharmacodynamics PK-PD model Flurbiprofen Experimental teaching |
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