蒙古族高血压患者血管紧张素的变化及意义

目的探讨蒙古族高血压患者血管紧张素水平的民族差异性,为蒙古族高血压患者制订更有针对性的防治措施提供依据。方法收集蒙古族和汉族高血压患者、血压正常高值者、正常血压者各30例。各组研究对象分别检测血浆血管紧张素Ⅱ(AngⅡ)、血管紧张素(1-7)[Ang(1-7)]水平。结果各组间年龄、性别、体质指数等基本情况差异无统计学意义。(1)蒙古族与汉族AngⅡ水平均随血压升高而升高,Ang(1-7)水平随血压降低而降低。(2)蒙古族高血压组与汉族高血压组、蒙古族血压正常高值组与汉族血压正常高值组、蒙古族血压正常组与汉族血压正常组之间的AngⅡ、Ang(1-7)水平差异均有统计学意义(均为P<0.05)。蒙古族的AngⅡ水平高于汉族,蒙古族的Ang(1-7)水平低于汉族,差异均有统计学意义(均为P<0.05)。结论血管紧张素改变具有民族差异性,蒙古族人群与汉族人群相比较,在血压正常期血管紧张素水平已较高。

Change of plasma angiotensin level in Mongolian nationality patients with hypertension

Objective To investigate the change and difference of plasma angiotensin level between Mongolian and HaM nationality patients with hypertension. Methods Ninety Mongolian nationality subjects with normotension （n = 30）, prehypertension （n = 30） or hypertension （n = 30）, and 90 HaM nationality subjects with normotension （n = 30）, prehypertension （ n = 30 ） or hypertension （ n = 50） were enrolled in this study. Plasma angiotensin H （ Ang Ⅱ） and angiotensin （ 1-7 ） [ Ang（ 1-7 ） ] were measured in all subjects. Results The basic characteristics were similar among each group. Plasma Ang Ⅱ level was significantly higher and Ang（ 1-7 ） was significantly lower in Mongolian nationality subjects than in HaM nationality subjects （P 〈 0. 05 ）. Plasma Ang Ⅱ was increased and Ang（ 1-7 ） was decreased with the elevation of blood pressure in both Mongolian nationality and HaM nationality subjects. Conclusions Nationality difference in plasma angiotensin level should be taken into account in prevention and treatment of hypertension.