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| 抗骨增生片对兔膝骨关节炎软骨组织病理形态及MMP-1、TIMP-1的影响 | |
| 引用本文： | 尹学永,王志文,赵鑫.抗骨增生片对兔膝骨关节炎软骨组织病理形态及MMP-1、TIMP-1的影响[J].河北中医药学报,2011,26(2):3-4,2. |
| 作者姓名： | 尹学永 王志文 赵鑫 |
| 作者单位： | 1. 河北省秦皇岛市第二医院,秦皇岛,066600 2. 河北联合大学中医学院,唐山,063000 3. 秦皇岛市中医医院,秦皇岛,066000 |
| 基金项目： | 秦皇岛市科学技术研究与发展计划项目:No 201001A332 |
| 摘 要： | 目的:观察抗骨增生片对兔膝骨关节炎软骨组织病理形态、基质金属蛋白酶-1(MMP-1)及其抑制剂(TIMP-1)的影响,探讨抗骨增生片是否能调节关节软骨MMP-1及TIMP-1的表达而起到对软骨的保护作用.方法:30只日本大耳白兔随机分为3组:正常对照组(A),模型对照组(B),抗骨增生片组(C).用1.6%木瓜蛋白酶膝... |
| 关 键 词： | 抗骨增生片 膝骨关节炎 软骨组织 病理形态 基质金属蛋白酶-1 基质金属蛋白酶抑制剂-1 |
Effect of Anti-boneregeneration Tablets on MMP-1,TIMP-1 and Cartilaginous Pathomorphism in Rabbits with Knee Osteoarthritis |
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| YIN Xue-yong,WANG Zhi-wen,ZHAO Xin.Effect of Anti-boneregeneration Tablets on MMP-1,TIMP-1 and Cartilaginous Pathomorphism in Rabbits with Knee Osteoarthritis[J].Journal of Hebei Traditional Chinese Medicine and Pharmacology,2011,26(2):3-4,2. | |
| Authors: | YIN Xue-yong WANG Zhi-wen ZHAO Xin |
| Institution: | YIN Xue-yong WANG Zhi-wen ZHAO Xin(Qinhuangdao 066600) Second Hospital of Qinhuangdao City,Hebei Province |
| Abstract: | Objective: to observe the effect of anti-boneregeneration tablets on MMP-1,TIMP-1 and cartilaginous pathomorphism in rabbits with knee osteoarthritis,so to explore whether the tablets can protect the cartilage by regulating MMP-1 and TIMP-1 expression.Methods: 30 Japanese white rabbits were randomly divided into 3 groups: control group(A),model group(B) and Tablet group(C).Model rabbits with knee osteoarthritis were made by introcavitary injection with 1.6% papain.4 weeks after administration to C group,pat... |
| Keywords: | anti-boneregeneration tablets knee osteoarthritis cartilage pathomorphism matrix metalloproteinase-1(MMP-1) MMP-1 TIMP-1 |
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