| 羧乙基锗倍半氧化物对肝癌的化学预防作用研究 |
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| 引用本文： | 华新,黎丹戎,涂文升,陈艳华,黎远冬,邱莉. 羧乙基锗倍半氧化物对肝癌的化学预防作用研究[J]. 中国现代医学杂志, 2000, 10(6): 11-12 |
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| 作者姓名： | 华新 黎丹戎 涂文升 陈艳华 黎远冬 邱莉 |
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| 作者单位： | 1. 广西医科大学,南宁,530021
2. 广西肿瘤防治研究所 |
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| 基金项目： | 广西区卫生厅青年基金资助项目!(青9207) |
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| 摘 要： | 羧乙基锗倍半氧化物（Ｃａｒｂｏｘｙｅｔｈｙｌｇｅｒｍａｎｉｕｍ简称Ｇｅ－１３２）对体外肝癌细胞无明显直接杀伤作用，但能降低肝癌细胞在软琼脂上的集落形成率。在ＡＦＢ１致大鼠肝癌体内短期实验模型中发现，Ｇｅ－１３２具有抵抗黄曲素（ＡｌｆａｔｏｘｉｎＢ１简称ＡＦＢ１）降低超氧化物歧化酶（ＳｕｐｅｒｏｘｉｄｅＤｉｓｍｕｔａｓｅ简称ＳＯＤ）活力的作用，Ｇｅ－１３２的摄入时间，剂量可影响ＳＯＤ活力大小。提示Ｇ
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| 关 键 词： | 羧乙基锗倍半氧化物 预防 SOD 肝癌 |
LIVER CANCER CHEMOPREVENTION WITH CARBOXYETHYLGERMANIUM (Ge-132) |
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| Hou Huaxin,Li Danrong,Tu Wensheng,Guangxi Medical University,Nanning. LIVER CANCER CHEMOPREVENTION WITH CARBOXYETHYLGERMANIUM (Ge-132)[J]. China Journal of Modern Medicine, 2000, 10(6): 11-12 |
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| Authors: | Hou Huaxin Li Danrong Tu Wensheng Guangxi Medical University Nanning |
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| Affiliation: | Hou Huaxin,Li Danrong,Tu Wensheng,Guangxi Medical University,Nanning 530021 |
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| Abstract: | This paper report that cell growth and proliferation of BEL-7402 could not be efficiently inhibited by carboxyethylgermanium Ge-132. But it can be debased the cells colony formation rate in soft-agar. Ge-132 possessed the remarkable resistance effects on aflatoxinB1 AFB1 reduces Superoxide Dismutase (SOD) activity in vivo during AFB1 -induced hepato-carcinogenesis for short term model experiments. The SOD activity can be effected by the time and the dosage of Ge-132 englobement. The results indicated that antioxidative ability of Ge-132 is related to its anticarcinogenicity. Ge-12 can be used as a safe and effective chemoprevention agent. |
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| Keywords: | Carboxyethylgermanium Chemoprevention Superoxide Dismutase (SOD) |
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