调脂积冲剂对脂肪肝大鼠胰岛素抵抗的影响

目的——探讨调脂积冲剂防治脂肪肝的有效性、可靠性，及其对胰岛素抵抗的影响。方法——采用酒精合并高脂乳剂建立大鼠脂肪肝模型，以易善复和六味地黄丸为阳性对照，检测TC、TG、HDL-C、LDL-C、ALT、GGT和FBG，采用酶联免疫法测定血清胰岛素含量。胰岛B细胞功能评价采用稳态模式评估法，即胰岛素抵抗指数（HOMA-IR）=（FBG）·FINS／22．5。结果——调脂积冲剂能降低ALT、CGT、TC、TG、LDL-C、FBC和FINS的含量，降低胰岛素抵抗指数。讨论——调脂积冲剂能有效防治脂肪肝，其机制可能与其改善胰岛素抵抗有关。

The Effect of TiaozhiJi Emulsion on Insulin Resistance of the Fatty Liver Rat

Objective TiaozhiJi Emulsion of this fatty liver of the validity, reliability, and insulin resistance in the formation of fatty liver＇s role in the process. Methods Combined high - fat emulsion used alcohol fatty liver rat model toEssentiale andLiuwei- dihuangwan to as a positive control, Detected TC, TG, HDL - C, LDL - C, ALT and GGT, FBG, using enzyme - linked immunosorbent assay for determination of serum insulin levels. B islet cell function evaluation by homeostasis model assessment （HOMA） , or insulin resistance index （ HOMA - IR） = （ FBG ） · FINS/22. 5. Results The TC, TG, LDL - C, ALT and GGT, FBG, FINS, HOMA - IR, liver index were higher than those of the normal group, lower HDL - C group. TiaozhiJi Emulsion can reduce the liver index, lower ALT and GGT, TC, TG, LDL - C, FBG, FINS content, lower HOMA - IR. Conclusions TiaozhiJi Emulsion can treatment of fatty liver, improve its mechanism may be related to insulin resistance.