| LPS致热家兔诱导HSF1聚合对体温及脑内AVP含量的影响 |
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| 引用本文： | 金莲锦,白宁,曹宇.LPS致热家兔诱导HSF1聚合对体温及脑内AVP含量的影响[J].中国药理学通报,2008,24(1):45-49. |
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| 作者姓名： | 金莲锦 白宁 曹宇 |
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| 作者单位： | 中国医科大学基础医学院生理学教研室,辽宁,沈阳,110001 |
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| 基金项目： | 国家自然科学基金
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教育部高等学校博士学科点专项科研基金 |
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| 摘 要： | 目的探讨热休克因子1(HSF1)在脂多糖(LPS)致家兔发热过程中的作用及机制。方法70只家兔随机分为4组:正常对照组(N)、槲皮素组(Q)、脂多糖组(L)和槲皮素+脂多糖组(Q+L)。连续观察体温变化;Westernblot方法检测不同实验条件下下丘脑HSF1和热休克蛋白70(HSP70)的表达;放射免疫法检测下丘脑及腹中隔区(VSA)精氨酸加压素(AVP)含量的变化。结果①各组体温变化最大值(△Tmax)由低至高顺序为:Q组
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| 关 键 词： | 脂多糖 发热 热休克因子1 精氨酸加压素 槲皮素 |
| 文章编号： | 1001-1978（2008）01-0045-05 |
| 收稿时间： | 2007-07-28 |
| 修稿时间： | 2007-10-12 |
Effect of the polymerization of HSF1 on the febrile response and the content of vasopressin arginine in brain in LPS-induced fever rabbits |
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| JIN Lian-jin,BAI Ning,CAO Yu.Effect of the polymerization of HSF1 on the febrile response and the content of vasopressin arginine in brain in LPS-induced fever rabbits[J].Chinese Pharmacological Bulletin,2008,24(1):45-49. |
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| Authors: | JIN Lian-jin BAI Ning CAO Yu |
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| Abstract: | Aim To observe the effect of the polymerization of HSF1 on the febrile response in fever rabbits,and further to investigate HSF1 action in thermoregulation and the possible central mechanism.Methods 70 rabbits were divided randomly into 4 groups:the control group(N),the quercetin group(Q),the LPS-feverish group(L),the quercetin+LPS-feverish group(Q+L).Changes in body temperature were continually observed;the expression of HSF1 and HSP70 in hypothalamus was detected by Western blot;the content of AVP in hypothalamus and VSA was measured by radioimmunoassay.Results ① The sequence of the maximum change of temperature(△Tmax)from low to high:group Q
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| Keywords: | lipopolysaccharide(LPS) fever heat shock factor 1(HSF1) arginine vasopressin(AVP) quercetin(Que) |
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