| 粉防己碱对麻醉大鼠心肌缺血和缺血/再灌流诱发的心律失常的作用 |
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| 引用本文： | 唐仲进,陈红,朱铨英,苏定冯. 粉防己碱对麻醉大鼠心肌缺血和缺血/再灌流诱发的心律失常的作用[J]. 第二军医大学学报, 1992, 0(3) |
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| 作者姓名： | 唐仲进 陈红 朱铨英 苏定冯 |
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| 作者单位： | 第二军医大学训练部药理学教研室 200433(唐仲进，朱铨英)，长海医院心内科 200433(陈红)，第二军医大学训练部药理学教研室 200433(苏定冯) |
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| 摘 要： | 采用麻醉大鼠左冠状动脉前降支结扎及结扎5min后再开放,造成心肌缺血和缺血/再灌流损伤的模型,观察了粉防己碱(Tet)对心肌缺血及再灌流所诱发的心律失常的作用。静脉注射Tet 4mg·kg~(-1)后可明显降低心肌缺血及再灌流损伤所诱发的心律失常严重程度。
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| 关 键 词： | 抗心律失常药 心肌梗塞 心律失常 心肌再灌流 心肌再灌流损伤 动物 大鼠 |
Effects of Tetrandrine on Arrhythmias Resulting from A Coronary Artery Ligation and Reperfusion in Anesthetized Rats |
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| Tang Zhongjin,Chen Hong,Zhu Quanying,Su Dingfeng. Effects of Tetrandrine on Arrhythmias Resulting from A Coronary Artery Ligation and Reperfusion in Anesthetized Rats[J]. Former Academic Journal of Second Military Medical University, 1992, 0(3) |
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| Authors: | Tang Zhongjin Chen Hong Zhu Quanying Su Dingfeng |
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| Abstract: | The purpose of this study is to investigate the effects of intravenous tetrandrine (Tet) on the outcome of myocardial ischemia and reperfusion. Tet 4mg- kg-1 iv significantly reduced arrhythmias resulting from a coronary artery ligation and reperfusion. It is suggested that Tet may be a prospective anti-arrhythmic drug in ischemic heart disease. |
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| Keywords: | anti-arrhythmia agents myocardial infarction arrhythmia myocardial reperfusion myocardial reperfusion injury animal rats |
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