根尖囊肿上皮细胞增殖与郎格罕细胞分布的关系

目的 分析根尖囊肿衬里上皮细胞增殖及其与郎格罕细胞分布的关系。方法 收集23例经组织病理学确诊的根尖囊肿石蜡标本，分别进行增殖细胞标记Ki-67和郎格罕细胞标记S-100的免疫组化染色，观察根尖囊肿衬里上皮的细胞增殖及其与郎格罕细胞分布的关系。结果 衬里上皮内的Ki-67阳性的细胞数目与结缔组织囊壁内的S-100阳性的细胞数目呈正相关（P〈0．05），但与衬里上皮内的S-100阳性的细胞数目无相关关系（P〉0．05）。结论 结缔组织囊壁中的郎格罕细胞数目与衬里上皮的增殖活性呈正相关，提示囊壁内由郎格罕细胞参与介导的免疫反应可能有促进上皮增殖的作用。

Relation between the proliferation of epithelial lining cell and the distribution of Langerhans, cell in radicular cysts

Objective To analyze the relation between the proliferation of epithelial lining cell and the distribution of Langerhans' cell in radicular cysts.Methods 23 examples of radicular cysts were immunohistochemically analyzed for the distribution of Langerhans, cell and proliferative activity as indicated by positivity for S-100 and Ki-67 respectively.Results The number of Ki-67 cells in epithelial lining is related to that of S-100 cells in cyst wall(P<0.05), however, there is no correlation between Ki-67 cells and S-100 cells in epithelial lining (P>0.05).Conclusion The immune responses induced by Langerhans, cell in cyst wall perhaps can accelerate the proliferation of epithelia.