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| E-cadherin表达与葡萄胎恶变的关系 | |
| 引用本文： | 张秀芬,陈素琴,张杰英,张静. E-cadherin表达与葡萄胎恶变的关系[J]. 中国妇幼保健, 2008, 23(13): 1864-1866 |
| 作者姓名： | 张秀芬 陈素琴 张杰英 张静 |
| 作者单位： | 1. 沧州医学高等专科学校妇产科 2. 河北医科大学第二附属医院妇产科,河北,石家庄,050000 3. 河北医科大学第二附属医院病理科 |
| 摘 要： | 目的:探讨E-cadherin与葡萄胎恶变的关系。方法:34例葡萄胎患者随访>2年10例发生恶变(恶变组),24例未发生恶变(未恶变组)。应用免疫组织化学方法研究葡萄胎恶变组与未恶变组石蜡包埋标本E-cadherin的表达状况。结果:恶变组E-cadherin的表达明显低于未恶变组(P=0.014),恶变前后E-cadherin的表达无差异(P=0.457)。结论:E-cadherin的表达与其侵袭性相关,是葡萄胎恶变发生的早期事件。 |
| 关 键 词： | 葡萄胎 E-cadherin 免疫组化 |
| 文章编号： | 1001-4411(2008)13-1864-03 |
| 修稿时间： | 2007-06-18 |
The expression of e-cadherin gene relate with malignant transformation in hydatidiform mole |
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| Abstract: | Objective:To elucidate the relations between E-cadherin gene expression and malignant transformation in hydatidiform mole.Methods:Immunochemistry was used.A total of 34 cases hydatidiform mole,24 cases non-malignant transforming mole,and 10 cases malignant transforming mole were investigated.Results:The expression of E-cadherin was higher in nonmalignant hydatidiform than that in malignant(P=0.014).The expression in both the two genes had no significant diference in moles that progressed into postmolar tumor compared with those that remitted spontaneously after evacuation.Conclusion:The expression of E-cadherin is correlated with the invasive transformation of trophoblast,and maybe it is the premise of invasiveness of hydatidiform mole. |
| Keywords: | E-cadherin Hydatidiform mole invasiveness Immunohistochemistry |
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