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Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations |
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| Authors: | M. Hufnagel K. Sixel F. Hammer A. Kropec I. G. Sava C. Theilacker R. Berner J. Huebner |
| Affiliation: | 1. Section of Pediatric Infectious Diseases and Rheumatology, Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Mathildenstr. 1, 79106, Freiburg, Germany 2. Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Freiburg, Germany 3. Cnopf Children’s Hospital, Nuremberg, Germany 4. ZIEL, Research Center for Nutrition and Food Science, CDD Center for Diet and Disease, Technical University Munich, Freising-Weihenstephan, Germany 5. Arud Center for Addiction Medicine, Zurich, Switzerland 6. University Children’s Hospital, Technical University Dresden, Dresden, Germany 7. Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University Munich, Munich, Germany |
| Abstract: | Three different commercially available polyvalent immune globulins (IG) were investigated for the existence of antibodies against cell wall carbohydrates of four different E. faecalis serotypes (using a cell wall carbohydrate-enzyme-linked immunosorbent assay), and whether these antibodies mediated opsonic killing (using an opsonic-killing assay). All three IG preparations contained antibodies against all four serotypes (CPS-A to CPS-D). However, only one of the three IG preparations showed opsonic killing against all four serotypes. Average killing was higher against serotypes A and B (72 and 79 %, respectively) than against serotypes C and D (30 and 37 %, respectively). Such IG preparations could play a role as an adjuvant therapeutic option in life-threatening infections with E. faecalis, particularly when resistant strains are involved. |
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