Endotoxin-induced lung hemorrhages in obstructive jaundiced rats |
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Authors: | Ryojin Uchino MD Naoyuki Saito Takehisa Hiraoka Seiki Tashiro Yoshimasa Miyauchi |
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Institution: | (1) The First Department of Surgery, Kumamoto University Medical School, 1670 Takehara, Yatsushiro, 866 Kumamoto, Japan |
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Abstract: | Endotoxemia in patients with biliary obstruction contributes to the high morbidity and mortality rates following surgery.
We developed an animal model of disseminated intravascular coagulation (DIC) in rats on which bile duct ligation was performed
following an injection of endotoxin (200 μg/kg bw). Macroscopic hemorrhages and microthrombi in the lung were found in jaundiced
rats 6 hours after the injection of endotoxin and yet these phenomena were not found in non-jaundiced rats following an injection
of the same amount of endotoxin. Coagulation studies also revealed characteristic findings of DIC in the jaundiced rats following
the injection of endotoxin. This study confirms that obstructive jaundice is one of the main predisposing factors in the course
of endotoxin-induced DIC. |
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Keywords: | obstructive jaundice endotoxin disseminated intravascular coagulation |
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