一起病毒性心肌炎爆发流行的调查分析

目的：阐明病因和流行因素，为本病的防治提供依据。方法：对疫区环境和人群进行现场流行病学调查，同时采集患者和高危人群的血和粪便等标本用细胞和乳小白鼠进行病原分离和血清中和抗体检测，用原代猴肾细胞进行病毒鉴定。结果：本次流行发病９１人，病死１３人，罹患率为１４８５％；病死率为１４６１％。临床和病理诊断为病毒性心肌炎，流行病学调查结果也符合病毒性心肌炎的流行特点。从患者体内分离到６株柯萨奇Ｂ４病毒，患者和高危人群血清中柯萨奇Ｂ４病毒抗体有升高。结论：本次心肌炎爆发流行是由柯萨奇Ｂ４病毒污染水源引起。

Investigation and Analysis of a Outbreak of the Viral Myocarditis

Objective: To study on causes and epidemic factors of viral myocarditis for its prevention and treatment. Methods: To investigate on the epidemic scene,the patients and the health in the epidemic area. We took the blood and faeces of them and isolated the pathogens and tested the antibody from the samples by the cell culture and infant mice, then identified by the original monkey cells. Results: The disease occurred in summer and autumn. The contaminated well water was source of the infection. The most of patients were the youth and the women. There were several patients in the family. The patients showed typical symptoms and pathological changes of viral myocarditis.The incidence is 14 85% and the mortality is 14 6%. 6 strains of Coxsackie B4 virus were isolated. The level of antibody against Coxsackie B4 virus in the patients and the health increased. Conclusion: The outbreak of the viral myocarditis caused by the contaminated water of CoxB4 virus.