C反应蛋白与冠心病病变程度的相关性

目的研究C反应蛋白（CRP）与冠心病病变程度的关系。方法测定经冠状动脉造影确诊的98例冠心病患者血浆CRP浓度。98例患者被分为3组:稳定型心绞痛组（n=32）、不稳定型心绞痛组（n=46）和急性心肌梗死组（n=20）;又根据血管病变程度分为单支血管病变组（n=56）及多支血管病变组（n=42）;同时以冠状动脉造影排除冠心病的23例患者作为对照组,比较各组间血浆CRP浓度。结果冠心病患者各组CRP浓度均较正常对照组增高（P<0.05）。在冠心病各亚组中,不稳定型心绞痛组血浆CRP浓度高于稳定型心绞痛组,而急性心肌梗死组CRP浓度分别高于稳定型心绞痛和不稳定型心绞痛组（P<0.01）。多支血管病变组CRP含量更显著高于单支血管病变组（P<0.01）。结论血浆CRP浓度与冠心病病变程度有密切关系。

Correlation between serum C-reactive protein and severity of coronary artery disease

AIM To assess the correlation of serum C-reactive protein(CRP) and the severity of coronary artery disease(CAD).METHODS Ninety-eight cases diagnosed with CAD by coronary angiography(CAG) were divided into three groups: stable angina(32 cases),unstable angina(46 cases) and acute myocardial infarction(20 cases).Twenty-three cases with normal angiography were used as the control.single injuries(56 cases) and complex injuries groups (42cases).The serum content of CRP was measured.RESULTS CRP was higher in the cases with CAD than in controls(P<0.05).The serum level of CRP was significantly higher in unstable angina group than in stable angina and the level of CRP in AMI group was markedly higher than the above 2 groups(P<0.00).In complex artery narrowing group,the CRP content was significantly higher compared with that with single artery injuries(P<0.01).CONCLUSION There is a close relationship between the serum level of CRP and the severity of coronary artery disease.