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Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia |
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| Authors: | Chul-Su Yang Hye-Mi Lee Ji-Yeon Lee Jeong-Ah Kim Sung Joong Lee Dong-Min Shin Young-Ho Lee Dong-Seok Lee Jamel El-Benna Eun-Kyeong Jo |
| Affiliation: | 1. Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, 301-747, S. Korea 2. Department of Anatomy, College of Medicine, Chungnam National University, Daejeon, 301-747, S. Korea 3. Department of Oral Physiology, School of Dentistry, Seoul National University, 28 Yeongun-dong, Jongno-gu, Seoul, 110-749, S. Korea 4. College of animal resource sciences, Kangwon National University, Chunchon, 200-701, Korea 5. Inserm U773, Université Paris 7-Denis Diderot, Site Bichat, Paris, France 6. Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon, 301-747, S. Korea |
| Abstract: | BackgroundActivated microglia elicits a robust amount of pro-inflammatory cytokines, which are implicated in the pathogenesis of tuberculosis in the central nervous system (CNS). However, little is known about the intracellular signaling mechanisms governing these inflammatory responses in microglia in response to Mycobacterium tuberculosis (Mtb). |
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