白斑脱落粘膜上皮细胞与组织上皮细胞微核率相关性分析

目的 检测口腔白班患者脱落粘膜细胞微核细胞率及相应组织细胞微核细胞率，并进行相关性分析，为将该项指标应用于口腔白斑的治疗和判断预后提供依据。方法 采用Ｆｅｕｇｌｅｎ染色方法，对５９例单纯增生、３２例轻和中度异常增生性白斑及２８例重度异常增生性白斑和口腔鳞癌患者的口腔脱落粘膜细胞和组织上皮细胞微核进行了检测，同时检测了１００例健康人的口腔脱落粘膜细胞微核作为正常对照。结果 口腔白斑患者脱落粘膜细胞微

The correlation analysis between frequency of micronucleated cells of exfoliated oral mucosa cells and oral mucosa cells in different grading of oral leukoplakia lesions

Objective To provide evidence for using micronucleated cells of exfoliated oral mucosa cells in diagnosis and treatment of oral leukoplakias and chemopreventive studies of oral cancer. Methods Micronuclei of exfoliated oral mucosa cells and oral mucosa cells in 119 patients comprising 59 simple hyperplasia,32 mild and moderate oral leukoplakia and 28 severe oral leukoplakia and oral squamous carcinoma by Feulgen stain method were examined , and micronuclei of exfoliated oral mucosa cells in 100 normal persons were also examined.Results Frequency of micronucleated cells of exfoliated oral mucosa cells in oral leukoplakia lesions was higher than that of normal persons. Frequency of micronucleated cells of exfoliated oral mucosa cells had a positive correlation with oral leukoplakia lesions( r =0.999 7, P < 0.001) and with frequency of micronucleated cells of oral mucosa cells ( P <0.001). Conclusions Frequency of micronucleated cells of exfoliated oral mucosa cells are useful markers to the clinician to predict oral leukoplakia behaviour and prognosis and substitute for frequency of micronucleated cells of oral mucosa cells as intermediate endpoint in chemopreventive trials.