| 宫内缺氧对成年小鼠学习记忆能力的影响 |
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| 引用本文： | 王东红,王俊波,袁相贵,凌树才.宫内缺氧对成年小鼠学习记忆能力的影响[J].解剖学杂志,2008,31(2):204-206. |
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| 作者姓名： | 王东红 王俊波 袁相贵 凌树才 |
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| 作者单位： | 1. 浙江大学医学院解剖学教研室,杭州,310058;台州学院医学院解剖学教研室,台州318000
2. 浙江大学医学院解剖学教研室,杭州,310058 |
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| 摘 要： | 目的:探讨孕鼠宫内缺氧对成年小鼠学习记忆能力的影响。方法:用低张性缺氧模型致胎龄13、15、17d小鼠宫内缺氧,新生鼠P1、P7、P14、P28、P90脑组织作Nissl染色,观察海马CA3区锥体细胞层神经元数目及形态,P90小鼠行Morris水迷宫实验。结果:与正常组比较,宫内缺氧组小鼠海马CA3区锥体细胞层神经元数量明显减少,逃避潜伏期延长及穿环次数明显减少。结论:宫内缺氧导致小鼠海马CA3区锥体细胞层神经元数目减少及成年小鼠学习记忆能力降低。
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| 关 键 词： | 宫内缺氧 海马 迷宫学习 记忆 |
| 修稿时间： | 2007年3月9日 |
Effects of intrauterine hypoxia on the ability of learning and memory in adult mice |
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| Wang Donghong,Wang Junbo,Yuan Xianggui,LING Shucai.Effects of intrauterine hypoxia on the ability of learning and memory in adult mice[J].Chinese Journal of Anatomy,2008,31(2):204-206. |
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| Authors: | Wang Donghong Wang Junbo Yuan Xianggui LING Shucai |
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| Abstract: | Objective: To study effects of hypoxia in the uterus on the ability of learning and memory in adult mice. Methods: The number and form of the hippocampal CA3 pyramidal cells during postnatal development with hypoxia within the uterus was studied by Nissl staining, and the ability of learning and memory in adult mice was observed by Morris water maze. Results: Compared with the control group, the number of the hippocampal CA3 pyramidal neurons reduced significantly, the latency to escape platform became longer, and the cross times reduced significantly. Conclusion: Intrauterine hypoxia may reduce the number of the hippocampal CA3 pyramidal neurons and the ability of learning and memory in adult mice. |
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| Keywords: | intrauterine hypoxia hippocampus maze learning memory |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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