| 乳腺癌靶向治疗新进展 |
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| 引用本文： | 黄郴,陈晓耕. 乳腺癌靶向治疗新进展[J]. 医学综述, 2010, 16(4) |
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| 作者姓名： | 黄郴 陈晓耕 |
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| 作者单位： | 福建省市医院肿瘤外科,福州,350001 |
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| 摘 要： | 近年来乳腺癌靶向治疗发展迅速,出现了许多新的药物和治疗靶点,包括新的抗HER-2药物,针对其他酪氨酸激酶如Src和其他信号转导通路如PI3K/Akt/mTOR的抑制剂。与此同时,多靶点联合治疗和单克隆抗体介导的免疫治疗的思路也逐渐得到认可。主要综述这些新药物的效果和临床应用前景,并对治疗新思路和面临的问题和挑战进行探讨。
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| 关 键 词： | 乳腺癌 分子靶向 单克隆抗体 酪氨酸激酶抑制剂 |
Advances in Targeted Therapy of Breast Cancer |
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| HUANG Chen,CHEN Xiao-geng. Advances in Targeted Therapy of Breast Cancer[J]. Medical Recapitulate, 2010, 16(4) |
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| Authors: | HUANG Chen CHEN Xiao-geng |
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| Affiliation: | HUANG Chen,CHEN Xiao-geng.(Department of Oncological Surgery,Fujian Provincial Hospital,Fuzhou 350001,China) |
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| Abstract: | In recent years,significant advances have been made in our understanding of breast cancer and many new drugs and therapeutic targets have come into being,including novel anti-HER2 drugs,agents against tyrosine kinases including Src and other signaling pathways such as the PI3K/Akt/mTOR inhibitors;In the meanwhile,multi-targets therapy and monoclonal antibody mediated immunotherapy are being well established.This article mainly reviewed the effects and prospect of the new agents and discussed the novel thera... |
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| Keywords: | Breast cancer Molecular targeted therapy Monoclonal antibody Tyrosine kinases inhibitors |
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