Evidence that factor VII levels correlate strongly with fibrinopeptide A release: evaluation by an ex vivo method |
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Authors: | G Mariani G Iacopino R Pasquali-Lasagni |
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Institution: | (1) Thrombosis Center, Hematology, Department of Human Biopathology, University of Rome “La Sapienza”, Via Chieti 7, 1-00161 Rome, Italy;(2) Dipartmento di Chirurgia, Istituto Regina Elena, Viale Regina Elena 291, I-00161 Rome, Italy |
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Abstract: | Summary The generation of thrombin was estimated by an assay for fibrinopeptide A which was developed and employed to evaluate the
relationship between factor VII and thrombin release. The amount of fibrinopeptide A released correlated strongly, when assayed
in the early stages of the reaction, with factor VII coagulant activity levels in the rage 50–2,000 units/dl. The method was
then applied to study the relationship between factor VII and fibrinopeptide A in plasma from blood donors, women on the pill
and patients on oral anticoagulants (with a range of factor VII coagulant activity from 8.5 to 600 units/dl). The overall
evaluation of the relationship between factor VII and fibrinopeptide A showed a strong correlation which was higher for factor
VII coagulant activity (r=0.90) than for factor VII antigen levels (r=0.817). The regression analysis which best fitted the data was the multiplicative one, indicating that thrombin formation
increases faster when factor VII coagulant activity is in the upper part of the normal range or higher. In patients on oral
anticoagulants, the correlation between factor VII and fibrinopeptide A was very poor. Our data fit well with the findings
of the epidemiological studies in which high levels of factor VII coagulant activity were shown to be associated with an increased
incidence of data coronary artery disease. |
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Keywords: | Factor VII Fibrinopeptide A Arterial thrombosis Activated factor VII Extrinsic pathway |
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