| 心力衰竭患者血浆内皮素的变化及倍他乐克的影响 |
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| 引用本文： | 徐惠春,孙明,周宏研,贾真. 心力衰竭患者血浆内皮素的变化及倍他乐克的影响[J]. 中南大学学报(医学版), 1998, 0(5) |
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| 作者姓名： | 徐惠春 孙明 周宏研 贾真 |
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| 作者单位： | Department of Internal Medicine，Xiangya Hospital，Hunan Medical University，Changsha 410008 |
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| 摘 要： | 为探讨充血性心力衰竭（ＣＨＦ）患者血浆内皮素－１（ＥＴ－１）的变化及倍他乐克（Ｂｅｔａｌｏｃ）对之影响，采用放射免疫法及高效液相色谱法测定４３例ＣＨＦ患者血浆ＥＴ－１和去甲肾上腺素（ＮＥ）水平。４３例中２４例用倍他乐克＋常规治疗，１９例用常规治疗，疗程１月。结果表明：ＣＨＦ患者治疗前血浆ＥＴ－１和ＮＥ均显著升高，且与ＣＨＦ程度呈正相关；治疗后降低。常规治疗对ＥＴ－１和ＮＥ均无影响
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| 关 键 词： | 心力衰竭；内皮素；倍他乐克；去甲肾上腺素；治疗应用；药物疗法 |
Changes of plasma endothelin 1 in patients with congestive heart failure and the influence of metoprolol |
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| Xu HuichunPostgraduate,Resident: the First Hospital of Nanjing,Nanjing Sun Ming Zhou Hongyan. Changes of plasma endothelin 1 in patients with congestive heart failure and the influence of metoprolol[J]. Journal of Central South University. Medical sciences, 1998, 0(5) |
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| Authors: | Xu HuichunPostgraduate Resident: the First Hospital of Nanjing Nanjing Sun Ming Zhou Hongyan |
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| Affiliation: | Xu HuichunPostgraduate,Resident: the First Hospital of Nanjing,Nanjing 210006 Sun Ming Zhou Hongyan |
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| Abstract: | To investigate the alterations of plasma endothelin 1(ET 1) in patients with congestive heart failure(CHF) and the effects of metoprolol on it, plasma ET 1 and norepinephrine(NE) were measured in 43 patients using radioimmunoassay and high performance liquid chromatography methods. Twenty four patients were treated with metoprolol plus the routine therapy while the others were received the routine therapy only. The findings were that levels of plasma ET 1 and NE increased before the treatment, and decreased after the treatment with metoprolol for 1 month. There was no alteration of plasma ET 1 or NE in the control group. |
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| Keywords: | heart failure endothelin norepinephrine metoprolol therapeutical use |
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