| 下丘脑-垂体-肾上腺轴昼夜节律指标随青春期发育变化的特征 |
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| 引用本文： | 段晓楠,严双琴,汪素美,胡晶晶,方姣,龚纯,万宇辉,苏普玉,陶芳标,孙莹.下丘脑-垂体-肾上腺轴昼夜节律指标随青春期发育变化的特征[J].中华流行病学杂志,2018,39(8):1086-1090. |
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| 作者姓名： | 段晓楠 严双琴 汪素美 胡晶晶 方姣 龚纯 万宇辉 苏普玉 陶芳标 孙莹 |
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| 作者单位： | 230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室,243011 安徽省马鞍山市妇幼保健院,243011 安徽省马鞍山市妇幼保健院,230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室,230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室,230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室,230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室,230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室,230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室,230032 合肥, 安徽医科大学公共卫生学院儿少与妇幼保健学系/人口健康与优生安徽省重点实验室 |
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| 基金项目： | 国家自然科学基金（81673188）；安徽省教育厅自然科学基金重点项目（KJ2016A338） |
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| 摘 要： | 目的 描述下丘脑-垂体-肾上腺（HPA）轴昼夜节律指标随青春期发育变化的特征。方法 2015年10月选择安徽省马鞍山市3所小学1 070名2~3年级学生为研究对象，并于2016年和2017年开展随访调查。调查内容包括体格发育、青春期发育和HPA轴昼夜节律。收集清晨觉醒时、醒后30 min和晚上入睡时3个时点唾液样本，并计算HPA轴昼夜节律指标：皮质醇觉醒应答（CAR）、昼间皮质醇总分泌量及昼夜皮质醇斜率（DCS）。采用睾丸容积、乳房发育分别评价男女童青春期发育阶段。采用问卷调查收集出生日期、入睡与起床时间和每周体力活动等信息。采用非参数检验比较HPA轴昼夜节律基线各指标在基线、随访期及不同青春期发育进程中的差异。结果 随访期间，青春期发育启动组和持续发育组CAR值、CAR变化值均高于与持续未发育组，差异有统计学意义（CAR：Z值分别为8.551和4.680，均P<0.01；CAR变化值：Z值分别为4.079和2.700，均P<0.01）；青春期启动组昼间皮质醇总分泌量高于持续未发育组，差异有统计学意义（Z=2.591，P=0.010）。与持续未发育组相比，DCS变化值在青春期启动组和持续发育组中下降明显，差异有统计学意义（Z=-2.450，Z=-2.151；均P<0.05）。昼间皮质醇总分泌量变化值与DCS在不同青春期发育进程组儿童中差异无统计学意义（昼间皮质醇总分泌量变化值：χ2=2.747，P=0.253；DCS：χ2=4.554，P=0.032）。结论 HPA轴昼夜节律指标与青春期发育有关，CAR、昼间皮质醇总分泌量随青春期发育进行而升高，昼间皮质醇差值随青春期发育而下降。
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| 关 键 词： | 下丘脑-垂体-肾上腺轴 昼夜节律 青春期 |
| 收稿时间： | 2018/2/7 0:00:00 |
Developmental characteristics of circadian rhythms in hypothalamic-pituitary-adrenal axis during puberty |
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| Duan Xiaonan,Yan Shuangqin,Wang Sumei,Hu Jingjing,Fang Jiao,Gong Chun,Wan Yuhui,Su Puyu,Tao Fangbiao and Sun Ying.Developmental characteristics of circadian rhythms in hypothalamic-pituitary-adrenal axis during puberty[J].Chinese Journal of Epidemiology,2018,39(8):1086-1090. |
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| Authors: | Duan Xiaonan Yan Shuangqin Wang Sumei Hu Jingjing Fang Jiao Gong Chun Wan Yuhui Su Puyu Tao Fangbiao and Sun Ying |
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| Institution: | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China,Ma''anshan Maternal and Child Health Center, Ma''anshan 243011, China,Ma''anshan Maternal and Child Health Center, Ma''anshan 243011, China,Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China,Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China,Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China,Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China,Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China,Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China and Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China |
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| Abstract: | |
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| Keywords: | Hypothalamic-pituitary-adrenal axis Circadian rhythm Puberty |
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