Copper levels in patients with hematological malignancies |
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| Authors: | Georgia D Kaiafa Zoi Saouli Michael D Diamantidis Zisis Kontoninas Virginia Voulgaridou Maria Raptaki Stergiani Arampatzi Maria Chatzidimitriou Vasilios Perifanis |
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| Institution: | 1. James J. Peters VA Medical Center, Bronx, NY, USA;2. Columbia University Medical Center, New York, NY, USA;3. Mount Sinai School of Medicine, New York, NY, USA;4. Johns Hopkins University School of Medicine, Baltimore, MD, USA;5. Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, USA;1. Department of Hematology and Oncology, University Children''s Hospital, Belgrade, Serbia;2. Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia;3. Clinic of Hematology, Clinical Center of Serbia, Belgrade, Serbia;4. Department of Metabolic Diseases, Mother and Child Healthcare Institute, Belgrade, Serbia;5. Center of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia;6. Department of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia;7. Faculty of Medicine, University of Belgrade, Belgrade, Serbia |
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| Abstract: | BackgroundCopper levels are elevated in cancer patients compared to normal subjects. However, few studies have investigated the relationship between copper and hematological malignancies.Methods84 patients with hematological diseases were studied, along with 50 healthy individuals. Copper was measured by flame atomic absorption spectrometry. The patients were classified to 2 homogeneous groups, acute and chronic hematological neoplasms, respectively. For the patients with acute hematological malignancies, relapse and remission were investigated in relation to serum copper levels. For chronic hematological neoplasms, serum copper was connected either with stable or progressive disease. Zeta-chain-associated protein kinase 70 (ZAP70) and CD38 expression, along with the unmutated VH immunoglobulin genes (IgVH) status were also determined for the 22 chronic lymphocytic leukemia (CLL) patients.Results54 patients with relapse or progressive disease had elevated copper levels (mean value 1.8 mg/l), whereas 30 patients either in remission or in stable disease had normal copper levels (mean value 1.01 mg/l) (normal range 0.8–1.3 mg/l).ConclusionHence, our study indicates that serum elevated copper levels are associated with hematological malignancies either in relapse or in disease progression, whereas normal copper levels are linked with hematological neoplasms in remission or in stable disease. Furthermore, we report for the first time an association between high serum copper levels and several adverse prognostic markers in CLL, such as increased expression of ZAP70 and CD38, along with elevated percentage of unmutated IgVH. |
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