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生命早期饥荒暴露与成年期体质指数的关联分析
引用本文:孟若谷,司佳卉,吕筠,郭彧,卞铮,余灿清,周汇燕,谭云龙,裴培,陈君石,陈铮鸣,李立明. 生命早期饥荒暴露与成年期体质指数的关联分析[J]. 中华流行病学杂志, 2016, 37(11): 1450-1453
作者姓名:孟若谷  司佳卉  吕筠  郭彧  卞铮  余灿清  周汇燕  谭云龙  裴培  陈君石  陈铮鸣  李立明
作者单位:100191 北京, 北京大学公共卫生学院流行病与卫生统计学系;100191 北京, 北京大学公共卫生学院流行病与卫生统计学系;100191 北京, 北京大学公共卫生学院流行病与卫生统计学系;100730 北京, 中国医学科学院;100730 北京, 中国医学科学院;100191 北京, 北京大学公共卫生学院流行病与卫生统计学系;100730 北京, 中国医学科学院;100730 北京, 中国医学科学院;100730 北京, 中国医学科学院;100022 北京, 国家食品安全风险评估中心;英国牛津大学临床试验与流行病学研究中心;100730 北京, 中国医学科学院
基金项目:国家自然科学基金(81373082);香港Kadoorie Charitable基金;英国Wellcome Trust(088158/Z/09/Z,104085/Z/14/Z)
摘    要:目的 研究生命早期饥荒暴露对成年期BMI的影响。方法 研究对象来自中国慢性病前瞻性研究的基线调查,共94 052名研究对象纳入分析。将出生于1956年10月至1958年9月、1959年10月至1961年9月和1962年10月至1964年9月的研究对象分别划分为饥荒前出生组、饥荒期内出生组和饥荒后出生组(对照组)。采用线性回归模型计算饥荒暴露组成年期BMI的回归系数及其95%CI。采用似然比检验计算吸烟、饮酒和体力活动与饥荒暴露交互作用的P值。结果 在调整了其他影响因素后,仅在女性中发现,与饥荒后出生组相比,饥荒期内出生组成年期BMI较高(β=0.12,95%CI:0.03~0.22)。吸烟、饮酒均对饥荒与BMI间的关联存在效应修饰作用(交互作用均P<0.001),体力活动不存在(交互作用P=0.077)。结论 生命早期经历饥荒,尤其是胎儿期经历饥荒的女性成年期BMI较高。因此,保证生命早期营养水平对预防成年后超重/肥胖的发生具有重要意义。

关 键 词:体质指数  生命早期  饥荒
收稿时间:2016-07-06

Association between famine exposure during early life and BMI in adulthood
Meng Ruogu,Si Jiahui,Lyu Jun,Guo Yu,Bian Zheng,Yu Canqing,Zhou Huiyan,Tan Yunlong,Pei Pei,Chen Junshi,Chen Zhengming and Li Liming. Association between famine exposure during early life and BMI in adulthood[J]. Chinese Journal of Epidemiology, 2016, 37(11): 1450-1453
Authors:Meng Ruogu  Si Jiahui  Lyu Jun  Guo Yu  Bian Zheng  Yu Canqing  Zhou Huiyan  Tan Yunlong  Pei Pei  Chen Junshi  Chen Zhengming  Li Liming
Affiliation:Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Chinese Academy of Medical Sciences, Beijing 100730, China;Chinese Academy of Medical Sciences, Beijing 100730, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Chinese Academy of Medical Sciences, Beijing 100730, China;Chinese Academy of Medical Sciences, Beijing 100730, China;Chinese Academy of Medical Sciences, Beijing 100730, China;China National Center for Food Safety Risk Assessment, Beijing 100022, China;Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU), Nuffield Department of Population Health, University of Oxford, UK;Chinese Academy of Medical Sciences, Beijing 100730, China
Abstract:Objective To examine the influence of famine exposure during early life on BMI in adulthood. Methods A total of 94 052 participants recruited in the baseline survey of China Kadoorie Biobank were included in this study. The participants who were born between October 1956 and September 1958, between October 1959 and September 1961 and between October 1962 and September 1964 were classified as group born before famine, group born during famine and group born after famine (control group). The regression coefficients and 95% confidence intervals (CIs) for BMI of famine exposure groups were estimated by linear regression model. And P values for interaction between famine and smoking, alcohol use, physical activity were estimated by likelihood ratio tests. Results Compared with the group born after famine, in females, the group born during famine had higher BMI (coefficient: 0.12, 95%CI: 0.03-0.22) after adjusting other impact factors. Except physical activity (interaction: P<0.077), both smoking and alcohol use had modification effects on the associations between famine exposure and BMI (interaction: all P<0.001). Conclusion Famine exposure during early life, especially during fetal period, might increase risks of overweight and obesity in females. Therefore, it is important to ensure the adequacy of nutrition during early life to prevent overweight or obesity in adulthood.
Keywords:Body mass index  Early life  Famine
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