| 中老年人睡眠与外周血白细胞端粒长度的关联性分析 |
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| 引用本文： | 刘惠芬,李峰,王业红,陈江慧,彭东旭,陈静,谭林华,米雪,赵本华. 中老年人睡眠与外周血白细胞端粒长度的关联性分析[J]. 中华流行病学杂志, 2017, 38(7): 889-892 |
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| 作者姓名： | 刘惠芬 李峰 王业红 陈江慧 彭东旭 陈静 谭林华 米雪 赵本华 |
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| 作者单位： | 361102 厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室,361009 厦门市莲花医院体检科,361009 厦门市莲花医院体检科,361102 厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室,361009 厦门市莲花医院体检科,361102 厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室,361000 厦门市湖里区疾病预防控制中心地方病与慢性病防治科,361102 厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室,361102 厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室 |
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| 基金项目： | 厦门市科技计划（3502Z20144058）;大学生创业训练计划项目（2015Y0936） |
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| 摘 要： | 目的 探索中老年人群睡眠与外周血白细胞端粒长度的关联性,为提倡健康睡眠延缓衰老提供科学依据。方法 使用匹兹堡睡眠质量指数调查表（PSQI）及一般情况调查表,对176名中老年人进行睡眠质量状况调查;采用荧光定量PCR法测量外周血白细胞端粒相对长度,并进行相关和回归分析。结果 外周血白细胞端粒平均长度为（0.995±0.23）T/S,年龄与端粒长度呈负相关（r=-0.241,P=0.003）;睡眠与年龄有关,随着年龄的增加,睡眠质量更差（r=-0.230,P<0.01）、入睡时间更长（r=0.227,P<0.01）、睡眠时间更短（r=-0.486,P<0.01）、睡眠效率更差（r=-0.226,P<0.01）;校正性别、年龄、婚姻、学历、家庭月收入、居住形式、吸烟、饮酒、体育锻炼、基础疾病因素的影响后,线性回归分析显示睡眠时间（β=0.057,P<0.01）、入睡时间（β=-0.046,P<0.01）、睡眠质量（β=0.086,P<0.01）是外周血白细胞端粒长度的独立影响因素,表明睡眠时间越长、入睡时间越短、睡眠质量越好,端粒长度越长。结论 睡眠是影响中老年人群端粒长度的因素,优良的睡眠可能通过减缓端粒长度的缩短延缓衰老,鼓励在社区进行健康睡眠知识的宣教活动,提高睡眠质量。
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| 关 键 词： | 睡眠质量 衰老 端粒长度 |
| 收稿时间： | 2016-11-22 |
Association between sleep and leukocyte telomere length in middle-aged and older adults |
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| Liu Huifen,Li Feng,Wang Yehong,Chen Jianghui,Peng Dongxu,Chen Jing,Tan Linhu,Mi Xue and Zhao Benhua. Association between sleep and leukocyte telomere length in middle-aged and older adults[J]. Chinese Journal of Epidemiology, 2017, 38(7): 889-892 |
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| Authors: | Liu Huifen Li Feng Wang Yehong Chen Jianghui Peng Dongxu Chen Jing Tan Linhu Mi Xue Zhao Benhua |
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| Affiliation: | State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Department of Epidemiology, School of Public Health, Xiamen University, Xiamen 361102, China,Department of Health Examination, Lianhua Hospital, Xiamen 361009, China,Department of Health Examination, Lianhua Hospital, Xiamen 361009, China,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Department of Epidemiology, School of Public Health, Xiamen University, Xiamen 361102, China,Department of Health Examination, Lianhua Hospital, Xiamen 361009, China,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Department of Epidemiology, School of Public Health, Xiamen University, Xiamen 361102, China,Department of Endemic Disease and Chronic Disease, Huli Center for Disease Control and Prevention, Xiamen 361000, China,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Department of Epidemiology, School of Public Health, Xiamen University, Xiamen 361102, China and State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Department of Epidemiology, School of Public Health, Xiamen University, Xiamen 361102, China |
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| Abstract: | |
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| Keywords: | Sleep quality Aging Telomere length |
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