| 过氧化物酶体增殖物激活受体多态性及基因-基因交互作用对脉压的影响 |
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| 引用本文： | 周慧,丁一,武鸣,范伟,俞浩,周正元,顾淑君,张丽君,董晨,郭志荣. 过氧化物酶体增殖物激活受体多态性及基因-基因交互作用对脉压的影响[J]. 中华流行病学杂志, 2017, 38(10): 1404-1409 |
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| 作者姓名： | 周慧 丁一 武鸣 范伟 俞浩 周正元 顾淑君 张丽君 董晨 郭志荣 |
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| 作者单位： | 215021 苏州市工业园区疾病防治中心,215021 苏州市工业园区疾病防治中心,210009 南京, 江苏省疾病预防控制中心慢病所,215123 苏州大学医学部公共卫生学院流行病与卫生统计教研室,210009 南京, 江苏省疾病预防控制中心慢病所,215500 江苏省常熟市疾病预防控制中心慢病科,215500 江苏省常熟市疾病预防控制中心慢病科,215123 苏州大学医学部公共卫生学院流行病与卫生统计教研室,215123 苏州大学医学部公共卫生学院流行病与卫生统计教研室,215123 苏州大学医学部公共卫生学院流行病与卫生统计教研室 |
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| 基金项目： | 国家自然科学基金（81502869）;苏州市"科教兴卫"青年科技项目（KJXW2014060,KJXW2015063） |
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| 摘 要： | 目的 探讨过氧化物酶体增殖物激活受体（PPAR）单核苷酸多态性（SNP）以及基因-基因交互作用对脉压差的影响。方法 基于江苏省代谢综合征和多代谢异常综合防治研究（PMMJS）队列,采用单纯随机抽样方法随机抽取其中研究对象820例,选取3个PPARα、2个PPARδ和5个PPARγ的SNP位点并进行检测,运用广义多因子降维法（GMDR）模型检测10个SNP的基因-基因交互作用与高血压的关联。结果 PPARγ的rs1805192的突变基因型（PA+AA）携带者与野生型（PP）相比,脉压差水平显著变化（1.341 mmHg,95% CI：0.431~2.252 mmHg）。GMDR模型分析显示,在脉压差≥ 30 mmHg的亚组中,PPARα基因的rs135539、PPARδ的rs2016520、PPARγ的rs10865710、rs1805192、rs709158、rs3856806组成的六阶模型平均检验准确度为0.577,交叉验证一致性为10/10,为最优模型。而在脉压差≤ 40 mmHg的亚组中,二阶交互作用模型与脉压差显著相关,平均检验准确度为0.628,交叉验证一致性为10/10。结论 PPARγ的rs1805192多态性与脉压差水平有关联,PPARα基因的rs135539、PPARδ的rs2016520和PPARγ的rs10865710、rs1805192、rs709158、rs3856806六个SNP间基因-基因交互作用与脉压差间具有显著性关联。
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| 关 键 词： | 脉压差 过氧化物酶体增殖物激活受体 广义多因子降维法 交互作用 |
| 收稿时间： | 2017-02-06 |
Association and effects of gene-gene interactions between peroxisome proliferator-activated receptor and pulse pressure |
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| Zhou Hui,Ding Yi,Wu Ming,Fan Wei,Yu Hao,Zhou Zhengyuan,Gu Shujun,Zhang Lijun,Dong Chen and Guo Zhirong. Association and effects of gene-gene interactions between peroxisome proliferator-activated receptor and pulse pressure[J]. Chinese Journal of Epidemiology, 2017, 38(10): 1404-1409 |
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| Authors: | Zhou Hui Ding Yi Wu Ming Fan Wei Yu Hao Zhou Zhengyuan Gu Shujun Zhang Lijun Dong Chen Guo Zhirong |
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| Affiliation: | Suzhou Industrial Park Centers for Disease Control and Prevention, Suzhou 215021, China,Suzhou Industrial Park Centers for Disease Control and Prevention, Suzhou 215021, China,Department of Chronic Non-communicable Diseases Prevention and Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China,Department of Epidemiology and Health Statistics, School of Public Health, Soochow University, Suzhou 215123, China,Department of Chronic Non-communicable Diseases Prevention and Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China,Department of Chronic Non-communicable Diseases Prevention and Control, Changshu Center for Disease Control and Prevention, Changshu 215500, China,Department of Chronic Non-communicable Diseases Prevention and Control, Changshu Center for Disease Control and Prevention, Changshu 215500, China,Department of Epidemiology and Health Statistics, School of Public Health, Soochow University, Suzhou 215123, China,Department of Epidemiology and Health Statistics, School of Public Health, Soochow University, Suzhou 215123, China and Department of Epidemiology and Health Statistics, School of Public Health, Soochow University, Suzhou 215123, China |
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| Abstract: | |
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| Keywords: | Pulse pressure Peroxisome proliferator-activated receptors Generalized multifactor dimensionality reduction Interaction |
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