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体质指数和腰围对浙江地区成年人糖尿病发生影响的前瞻性研究
引用本文:王浩,胡如英,钱一建,王春梅,谢开婿,陈玲琍,潘东霞,张益丹,卞铮,郭彧,Fiona Bragg,俞敏,李立明,陈铮鸣.体质指数和腰围对浙江地区成年人糖尿病发生影响的前瞻性研究[J].中华流行病学杂志,2018,39(6):810-815.
作者姓名:王浩  胡如英  钱一建  王春梅  谢开婿  陈玲琍  潘东霞  张益丹  卞铮  郭彧  Fiona Bragg  俞敏  李立明  陈铮鸣
作者单位:310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所,310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,102308 北京, 中国医学科学院慢性病前瞻性研究项目办公室,102308 北京, 中国医学科学院慢性病前瞻性研究项目办公室,OX12JD 英国牛津大学临床与流行病学研究中心纳菲尔德人群健康系,310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所,100191 北京大学公共卫生学院,OX12JD 英国牛津大学临床与流行病学研究中心纳菲尔德人群健康系
基金项目:国家重点研发计划精准医学研究重点专项(2016YFC0900500,2016YFC0900501,2016YFC0900502,2016YFC0900504);中国香港Kadoorie Charitable基金;英国Wellcome Trust (202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z)
摘    要:目的 探讨BMI和腰围对成年人糖尿病发病的影响。方法 使用"中国慢性病前瞻性研究"(CKB)浙江省桐乡市数据,剔除基线时自报患有恶性肿瘤、心脏病、脑卒中和糖尿病患者后,纳入分析30~79岁53 916人。采用Cox比例风险模型计算糖尿病发病风险比(HR)。结果 调查对象累计随访391 512人年(平均随访7.26年)。随访期间,男性944人和女性1 643人被新诊断为糖尿病。多因素调整后,与BMI正常组的人群相比,男性超重和肥胖组糖尿病发病的HR值(95%CI)分别为2.72(95%CI:2.47~2.99)和6.27(95%CI:5.33~7.36)。女性超重和肥胖组HR值(95%CI)分别为2.19(95%CI:2.04~2.36)和3.78(95%CI:3.36~4.26);与腰围正常组的人群相比,男性Ⅰ级(85.0~89.9)和Ⅱ级中心性肥胖(≥ 90.0)组糖尿病发病的HR值(95%CI)分别为2.56(2.22~2.95)和4.66(4.14~5.24)。女性Ⅰ级(80.0~84.9)和Ⅱ级中心性肥胖(≥ 85.0)组HR值(95%CI)分别为1.99(1.80~2.21)和3.16(2.90~3.44)。结论 超重/肥胖以及中心性肥胖人群糖尿病发病风险均会升高。在开展控制体重预防糖尿病的同时,更应控制腰围。

关 键 词:糖尿病  体质指数  腰围  前瞻性研究
收稿时间:2017/10/18 0:00:00

Prospective study on the effect of BMI and waist circumference on diabetes of adults in Zhejiang province
Wang Hao,Hu Ruying,Qian Yijian,Wang Chunmei,Xie Kaixu,Chen Lingli,Pan Dongxi,Zhang Yidan,Bian Zheng,Guo Yu,Fiona Bragg,Yu Min,Li Liming and Chen Zhengming.Prospective study on the effect of BMI and waist circumference on diabetes of adults in Zhejiang province[J].Chinese Journal of Epidemiology,2018,39(6):810-815.
Authors:Wang Hao  Hu Ruying  Qian Yijian  Wang Chunmei  Xie Kaixu  Chen Lingli  Pan Dongxi  Zhang Yidan  Bian Zheng  Guo Yu  Fiona Bragg  Yu Min  Li Liming and Chen Zhengming
Institution:Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China,Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China,Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China,Department of China Kadoorie Biobank, Chinese Academy of Medical Sciences, Beijing 102308, China,Department of China Kadoorie Biobank, Chinese Academy of Medical Sciences, Beijing 102308, China,Clinical Trial Service and Epidemiological Studies Unit(CTSU), University of Oxford, Oxford OX12JD, UK,Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China,School of Public Health, Peking University, Beijing 100191, China and Clinical Trial Service and Epidemiological Studies Unit(CTSU), University of Oxford, Oxford OX12JD, UK
Abstract:
Keywords:Diabetes  Body mass index  Waist circumference  Prospective study
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