| 基因多态性对疫苗免疫应答影响的研究进展 |
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| 引用本文： | 曹嘉倩,李靖欣,王圆媛,朱凤才. 基因多态性对疫苗免疫应答影响的研究进展[J]. 中华流行病学杂志, 2018, 39(11): 1515-1518 |
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| 作者姓名： | 曹嘉倩 李靖欣 王圆媛 朱凤才 |
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| 作者单位： | 211166 南京医科大学公共卫生学院,210009 南京, 江苏省疾病预防控制中心疫苗临床评价所,211166 南京医科大学公共卫生学院,211166 南京医科大学公共卫生学院;210009 南京, 江苏省疾病预防控制中心疫苗临床评价所 |
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| 基金项目： | 国家科技重大专项（2015ZX09101044） |
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| 摘 要： | 基因在免疫系统应答过程中扮演着重要的角色,不同的基因位点可能引起疫苗免疫应答率的高低差异。本文对基因多态性与疫苗免疫应答的文献进行综述,旨在探究基因多态性会对疫苗免疫应答产生的影响,从基因水平上探讨个体接种疫苗后产生免疫应答的效果,为个体化免疫发展策略提供科学依据。综述结果显示人类白细胞抗原基因、各类细胞因子及其受体基因、Toll样受体类基因的单核苷酸多态性都会影响疫苗免疫应答。
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| 关 键 词： | 基因 疫苗 免疫应答 |
| 收稿时间： | 2018-06-05 |
Progress in research of influence of gene polymorphisms on immune response |
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| Cao Jiaqian,Li Jingxin,Wang Yuanyuan and Zhu Fengcai. Progress in research of influence of gene polymorphisms on immune response[J]. Chinese Journal of Epidemiology, 2018, 39(11): 1515-1518 |
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| Authors: | Cao Jiaqian Li Jingxin Wang Yuanyuan Zhu Fengcai |
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| Affiliation: | School of Public Health, Nanjing Medical University, Nanjing 211166, China,Department of Vaccine Clinical Evaluation, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China,School of Public Health, Nanjing Medical University, Nanjing 211166, China and School of Public Health, Nanjing Medical University, Nanjing 211166, China;Department of Vaccine Clinical Evaluation, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China |
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| Abstract: | Genes play an important role in the immune system response, and different gene loci may result in different vaccine immune response rates. This review focuses on the correlation between gene polymorphisms and vaccine immune response in order to investigate the influence of gene polymorphisms on the immune response to vaccines. It discusses the effect of an individual''s immune response after vaccination at genetic level and provides a scientific basis for individualized immune development strategies. It reveals that human leukocyte antigen genes, various cytokines and their receptor genes, and Toll-like receptor genes all affect the vaccine immune response. |
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| Keywords: | Gene Vaccine Immune response |
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