Protective effect of a cysteine prodrug and antioxidant,L-2-oxothiazolidine-4-carboxylate,against ethanol-induced gastric lesions in rats |
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| Authors: | Meshal Al Moutaery Hannan Al Rayes Ramaiz Al Swailam Ibrahim Elfaki Haseeb Ahmad Khan Mohammad Arshaduddin Mohammad Tariq |
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| Institution: | 1. Prince Sultan Cardiac Center, Armed Forces Hospital, Riyadh, Saudi Arabia;2. Department of Medicine, Armed Forces Hospital, Riyadh, Saudi Arabia;3. Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia;4. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia |
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| Abstract: | Earlier studies have suggested an important role of glutathione (GSH) in cytoprotection against free radicals induced oxidative damage. This study reports gastroprotective effects of a cysteine precursor, L-2-oxothiazolidine-4-carboxylate (OTC), in experimental models of gastric secretion and ulceration. Acid secretion studies (volume and acidity) were undertaken in pylorus-ligated rats whereas the gastric lesions were induced by ethanol. Different groups of animals were treated with OTC (0, 100, 200 and 400 mg/kg). The levels of gastric wall mucus, nonprotein sulfhydryls (NP-SH) and myeloperoxidase (MPO) were measured in the glandular stomach of rats following ethanol-induced gastric lesions. Both medium and high doses of OTC significantly reduced the volume and acidity of gastric secretion in pylorus-ligated rats. Pretreatment with OTC significantly and dose-dependently attenuated the formation of ethanol-induced gastric lesion. OTC significantly protected the gastric mucosa against ethanol-induced depletion of gastric wall mucus, NP-SH and MPO. The gastroprotective effects of OTC may be attributed to its ability to inhibit neutrophils activity and replenish GSH demand. |
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