中国首例输入性黄热病病例的流行病学调查

目的 描述中国首例输入性黄热病病例的发病就诊过程和流行病学特征,为今后黄热病输入性病例的管理提供依据。方法 通过传染病监测系统及时发现病例并对病例进行流行病学调查,采集病例血液和唾液标本,应用实时荧光PCR方法进行黄热病核酸检测。结果 患者为男性,32岁,2016年3月8日在安哥拉突发寒颤高热,10日凌晨抵京,下午入院治疗,11日北京市CDC实验室检测患者血液标本黄热病毒核酸阳性。患者症状持续加重,肝肾衰竭,肝性脑病,多器官功能衰竭,后于16日死亡。患者在发病前6日内有明确蚊虫叮咬史。结论 该病例为我国首例输入性黄热病确诊病例。对此例病例开展的流行病学调查、实验室检测和疫情处置措施,为今后对输入性黄热病疫情的规范处置提供了科学依据。

The first confirmed imported case of yellow fever in China

Objective To describe the epidemiological characteristics of the first confirmed imported case of yellow fever in China. Methods This case was reported through the Infectious Disease Surveillance Program. Information on epidemiology and clinical manifestation of the case was collected through case interview and related medical records. Blood and saliva samples of the case were collected and tested by real-time PCR. Results The patient was male, 32 years old, and suffered a sudden onset of fever without other symptoms, on March 8^th, 2016. The patient arrived in Beijing at midnight on March 10^th. Condition of the patient got progressively worsened, with both liver and renal failures, hepatic encephalopathy, multiple organ failures and DIC, finally died on March 16^th. Serum of the case was positive for yellow fever virus by real time PCR. The patient was bit by mosquitoes six days before the onset of fever in Luanda, Angola. Conclusion This report summarized related information on the first confirmed but imported case of yellow fever in China that was helpful to the management of other imported yellow fever cases in the future.