| 细胞学检测为非典型鳞状细胞且人乳头瘤病毒阴性妇女的宫颈癌患病风险评估 |
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| 引用本文： | 张莉,冯瑞梅,胡尚英,张倩,赵雪莲,热米拉&#;热扎克,陈凤,张询,潘秦镜,赵方辉,乔友林. 细胞学检测为非典型鳞状细胞且人乳头瘤病毒阴性妇女的宫颈癌患病风险评估[J]. 中华流行病学杂志, 2016, 37(6): 801-804 |
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| 作者姓名： | 张莉,冯瑞梅,胡尚英,张倩,赵雪莲,热米拉&# 热扎克,陈凤,张询,潘秦镜,赵方辉,乔友林 |
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| 作者单位： | 100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院病理科;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院细胞学室;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院;100021 北京, 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院 |
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| 基金项目： | 国家自然科学基金优秀青年科学基金(81322040) |
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| 摘 要： | 目的 评估宫颈癌筛查中非典型鳞状细胞(ASC-US)但人乳头瘤病毒(HPV)阴性的妇女罹患中度及以上宫颈上皮内瘤样病变(CIN2+)的风险。方法 汇总1999-2008年在我国开展的17项以人群为基础的宫颈癌筛查横断面研究,共30371名17~59岁妇女参加筛查,所有妇女均进行了液基细胞学检查(LBC)、HPV检测(hybrid capture 2, HC2)和醋酸染色肉眼观察法(VIA),任一结果阳性者转诊阴道镜。最终28810名具有完整细胞学、HPV、病理检测结果的妇女纳入分析,分别以细胞学正常且HPV阴性组(LBC-/HPV-)、细胞学正常组(LBC-)为参照,评估细胞学为ASC-US且HPV阴性组(ASC-US/HPV-)的CIN2+患病风险。结果 LBC-/HPV-、LBC-和ASC-US/HPV-组分别有22003、24139和1834名妇女,CIN2+的患病率分别为0.05%、0.36%和0.16%。分别以LBC-/HPV-组、LBC-组为参照,ASC-US/HPV-组罹患CIN2+的风险分别为3.00(95%CI:0.85~10.65)和0.46(95%CI:0.15~1.45),其校正OR值分别为4.00(95%CI:1.08~14.87)、0.47(95%CI:0.15~1.49)。结论 ASC-US/HPV-妇女CIN2+的患病风险介于LBC-和LBC-/HPV-妇女之间。依据"同等风险、同等管理"的原则,可采用对LBC-者的3年筛查间隔,而对于卫生资源相对匮乏地区可采用对LBC-/HPV-者的5年筛查间隔。
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| 关 键 词： | 宫颈癌 筛查 轻度异常 风险 |
| 收稿时间： | 2015-11-26 |
Risk assessment on cervical cancer in women with cytology atypical squamous cells of undetermined significance but negative human papillomavirus |
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| Zhang Li,Feng Ruimei,Hu Shangying,Zhang Qian,Zhao Xuelian,Remila,#;Rezhake,Chen Feng,Zhang Xun,Pan Qinjing,Zhao Fanghui and Qiao Youlin. Risk assessment on cervical cancer in women with cytology atypical squamous cells of undetermined significance but negative human papillomavirus[J]. Chinese Journal of Epidemiology, 2016, 37(6): 801-804 |
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| Authors: | Zhang Li,Feng Ruimei,Hu Shangying,Zhang Qian,Zhao Xuelian,Remila&# Rezhake,Chen Feng,Zhang Xun,Pan Qinjing,Zhao Fanghui Qiao Youlin |
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| Affiliation: | Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Cytology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China |
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| Abstract: | |
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| Keywords: | Cervical cancer Screening Mild abnormal Risk |
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