| 中国18岁以下双生子出生体重与超重/肥胖的关联分析 |
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| 引用本文： | 刘青青,余灿清,高文静,曹卫华,吕筠,王胜锋,逄增昌,丛黎明,董忠,吴凡,汪华,吴先萍,王德征,王滨有,李立明.中国18岁以下双生子出生体重与超重/肥胖的关联分析[J].中华流行病学杂志,2016,37(4):464-468. |
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| 作者姓名： | 刘青青 余灿清 高文静 曹卫华 吕筠 王胜锋 逄增昌 丛黎明 董忠 吴凡 汪华 吴先萍 王德征 王滨有 李立明 |
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| 作者单位： | 100191 北京大学公共卫生学院流行病与卫生统计学系;100191 北京大学公共卫生学院流行病与卫生统计学系;100191 北京大学公共卫生学院流行病与卫生统计学系;100191 北京大学公共卫生学院流行病与卫生统计学系;100191 北京大学公共卫生学院流行病与卫生统计学系;100191 北京大学公共卫生学院流行病与卫生统计学系;266033 青岛市疾病预防控制中心;310051 杭州, 浙江省疾病预防控制中心;100013 北京市疾病预防控制中心慢性病防治所;200336 上海市疾病预防控制中心;210009 南京, 江苏省疾病预防控制中心;610041 成都, 四川省疾病预防控制中心;300011 天津市疾病预防控制中心非传染病预防控制所;150081 哈尔滨医科大学公共卫生学院流行病学教研室;100191 北京大学公共卫生学院流行病与卫生统计学系 |
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| 基金项目： | 卫生行业科研专项项目(201002007);教育部科学技术研究项目重大项目(310006) |
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| 摘 要： | 目的 分析出生体重与儿童时期超重/肥胖间的关联。方法 使用中国双生子登记系统基线调查的<18岁双生子人群(共8267对),采用双生子对内对照设计方法,探索出生体重与儿童青少年时期BMI及超重/肥胖之间的关联。结果 调整性别和卵型的影响后,出生体重每增加0.5 kg,超重/肥胖的风险:幼儿及学龄前期(≥ 2且<6岁)儿童增加0.87倍,学龄期(≥ 6且<12岁)儿童增加0.69倍,青春期(≥ 12且<18岁)青少年增加0.28倍。结论 双生子出生体重与幼儿及学龄期超重/肥胖存在正向关联,但在指导实施公共卫生干预措施时仍需谨慎。
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| 关 键 词： | 超重/肥胖 出生体重 双生子对内对照设计 |
| 收稿时间： | 2015/9/6 0:00:00 |
A co-twin control study on birth weight, overweight and obesity among children younger than 18 years old in China |
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| Liu Qingqing,Yu Canqing,Gao Wenjing,Cao Weihu,Lyu Jun,Wang Shengfeng,Pang Zengchang,Cong Liming,Dong Zhong,Wu Fan,Wang Hu,Wu Xianping,Wang Dezheng,Wang Binyou and Li Liming.A co-twin control study on birth weight, overweight and obesity among children younger than 18 years old in China[J].Chinese Journal of Epidemiology,2016,37(4):464-468. |
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| Authors: | Liu Qingqing Yu Canqing Gao Wenjing Cao Weihu Lyu Jun Wang Shengfeng Pang Zengchang Cong Liming Dong Zhong Wu Fan Wang Hu Wu Xianping Wang Dezheng Wang Binyou and Li Liming |
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| Institution: | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Qingdao Center for Disease Control and Prevention, Qingdao 266033, China;Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China;Department of Chronic and Non-communicable Disease Control and Prevention, Beijing Center for Disease Control and Prevention, Beijing 100013, China;Shanghai Center for Disease Control and Prevention, Shanghai 200336, China;Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China;Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China;Department of Chronic and Non-communicable Disease Control and Prevention, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China;Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China |
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| Abstract: | Objective To analyze the associations between birth weight and overweight/obesity among children. Methods A total of 8267 twin pairs younger than 18 years old from the Chinese National Twin Registry were included in the study. Associations between birth weight, childhood BMI and overweight/obesity were explored by this co-twin control study. Results After adjusting for sex and zygosity, when birth weight had an increase of 0.5 kg per fold, the OR values for overweight and obesity were 1.87(95%CI:1.40-2.48) for 2-6 year olds, 1.69(95%CI:1.16-2.46) for 6-12 year olds and 1.28(95%CI:0.80-2.07) for 12-18 year olds. Results from the stratified analysis in the 2-6 year-olds, statistically significant differences were seen. When birth weight increased 0.5 kg per fold, the risk of overweight and obesity increased by 0.87 times among the dizygotic twins, more than that of the monozygotic twins(OR=1.86, 95%CI:1.24-2.81). The risk for male twins was 1.12 times higher than that of female twins(OR=1.65, 95%CI:1.11-2.44). Conclusions Birth weight seemed associated with overweight and obesity for kids at early childhood or at age for schools. However, guidance on the implementation of public health interventions is still needed on these children. |
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| Keywords: | Overweight and obesity Birth weight Co-twin control study |
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