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浙江省成年人饮茶与脑卒中发生关联的前瞻性研究
引用本文:王浩,杜怀东,胡如英,钱一建,王春梅,谢开婿,陈玲琍,潘东霞,卞铮,郭彧,俞敏,李立明,陈铮鸣.浙江省成年人饮茶与脑卒中发生关联的前瞻性研究[J].中华流行病学杂志,2018,39(9):1200-1205.
作者姓名:王浩  杜怀东  胡如英  钱一建  王春梅  谢开婿  陈玲琍  潘东霞  卞铮  郭彧  俞敏  李立明  陈铮鸣
作者单位:310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所,OX3 7LF 英国牛津大学纳菲尔德人群健康系临床与流行病学研究中心,310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,314500 桐乡市疾病预防控制中心慢病科,102308 北京, 中国医学科学院慢性病前瞻性研究项目办公室,102308 北京, 中国医学科学院慢性病前瞻性研究项目办公室,310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所,100191 北京大学公共卫生学院,OX3 7LF 英国牛津大学纳菲尔德人群健康系临床与流行病学研究中心
基金项目:国家重点研发计划精准医学研究重点专项(2016YFC0900500,2016YFC0900501,2016YFC0900502,2016YFC0900504);中国香港KadoorieCharitable基金;英国WellcomeTrust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z)
摘    要:目的 探讨饮茶和成年人脑卒中发病的前瞻性关联。方法 使用“中国慢性病前瞻性研究”(CKB)浙江省桐乡市数据,剔除基线时自报患有恶性肿瘤、心脏病、脑卒中和糖尿病患者后,纳入分析30~79岁53 916人。采用Cox比例风险模型计算脑卒中发病风险比(HR)。结果 桐乡居民最主要的饮茶品种为红茶(79.78%),其次是绿茶(20.08%)。调查对象中,每周饮茶者的比例为31.27%,其中男性和女性分别为60.24%和10.30%;调查对象累计随访391 512人年(平均随访7.26年)。随访期间,1 487例男性和1 769例女性被新诊断为脑卒中。在调整了人口社会学因素、生活方式、BMI、腰围和SBP等多种危险因素后,脑卒中发病风险随日均饮茶克数的增加而降低,趋势性检验差异有统计学意义(P=0.000 6)。与非每周饮茶者相比,日均饮茶0.1~、3.0~和≥5.0 g者脑卒中发病HR值(95% CI)分别为0.93(0.85~1.00)、0.88(0.77~0.99)和0.79(0.69~0.89)。与非每周饮茶者相比,日均饮茶≥5 g者脑卒中发病HR值(95% CI)在吸烟和不吸烟人群中分别为0.71(0.59~0.86)和0.97(0.77~1.21),差异有统计学意义(P=0.040 0),在不饮酒与饮酒的人群中分别为0.70(0.58~0.84)和0.96(0.76~1.22),差异有统计学意义(P=0.040 0),在中心性肥胖与非中心性肥胖人群中分别为0.60(0.44~0.81)和0.86(0.73~1.01),差异有统计学意义(P=0.040 0)。结论 饮茶可以降低脑卒中发病风险。与非每周饮茶者相比,饮茶的保护作用在吸烟者、不饮酒者以及中心性肥胖者中更明显。

关 键 词:饮茶  脑卒中  前瞻性研究
收稿时间:2018/2/28 0:00:00

Association between tea drinking and stroke in adults in Zhejiang province: a prospective study
Wang Hao,Du Huaidong,Hu Ruying,Qian Yijian,Wang Chunmei,Xie Kaixu,Chen Lingli,Pan Dongxi,Bian Zheng,Guo Yu,Yu Min,Li Liming and Chen Zhengming.Association between tea drinking and stroke in adults in Zhejiang province: a prospective study[J].Chinese Journal of Epidemiology,2018,39(9):1200-1205.
Authors:Wang Hao  Du Huaidong  Hu Ruying  Qian Yijian  Wang Chunmei  Xie Kaixu  Chen Lingli  Pan Dongxi  Bian Zheng  Guo Yu  Yu Min  Li Liming and Chen Zhengming
Institution:Department of Chronic and Non-communicable Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China,Clinical Trial Service and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom,Department of Chronic and Non-communicable Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China,Department of Chronic and Non-communicable Disease Prevention and Control, Tongxiang County Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Chronic and Non-communicable Disease Prevention and Control, Tongxiang County Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Chronic and Non-communicable Disease Prevention and Control, Tongxiang County Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Chronic and Non-communicable Disease Prevention and Control, Tongxiang County Center for Disease Control and Prevention, Tongxiang 314500, China,Department of Chronic and Non-communicable Disease Prevention and Control, Tongxiang County Center for Disease Control and Prevention, Tongxiang 314500, China,Department of China Kadoorie Biobank, Chinese Academy of Medical Sciences, Beijing 102308, China,Department of China Kadoorie Biobank, Chinese Academy of Medical Sciences, Beijing 102308, China,Department of Chronic and Non-communicable Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China,School of Public Health, Peking University, Beijing 100191, China and Clinical Trial Service and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom
Abstract:
Keywords:Tea drinking  Stroke  Prospective study
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